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Synthesis 2018; 50(02): 323-329
DOI: 10.1055/s-0036-1590928
DOI: 10.1055/s-0036-1590928
paper
Organocatalytic Enantioselective Vinylogous Henry Reaction of 3,5-Dimethyl-4-nitroisoxazole with Trifluoromethyl Ketones
Further Information
Publication History
Received: 05 September 2017
Accepted: 12 September 2017
Publication Date:
04 October 2017 (online)
Abstract
The enantioselective vinylogous Henry reaction of 3,5-dimethyl-4-nitroisoxazole with trifluoromethyl ketones employing a bifunctional squaramide organocatalyst has been developed. A series of isoxazole bearing trifluoromethyl-substituted tertiary alcohols, 2-substituted (R)-1,1,1-trifluoro-3-(3-methyl-4-nitroisoxazol-5-yl)propan-2-ols, were obtained under these mild reaction conditions in good yields and moderate to good enantioselectivities
Key words
asymmetric synthesis - isoxazole - trifluoromethyl ketone - squaramide organocatalyst - vinylogous Henry reactionSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1590928.
- Supporting Information
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