Synlett 2017; 28(17): 2307-2310
DOI: 10.1055/s-0036-1590965
© Georg Thieme Verlag Stuttgart · New York

Convenient and Clean Synthesis of Isatins by Metal-Free Oxidation of Oxindoles

Wen-Ting Wei*, Wei-Wei Ying, Wen-Ming Zhu, Yi Wu, Yi-Ling Huang, Yi-Qi Cao, Yi-Ning Wang, Hongze Liang*
This research is sponsored by research funds of NBU (No. ZX2016000706), the foundation of Ningbo University (No. XYL17009), and the K. C. Wong Magna Fund in Ningbo University
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Publication History

Received: 19 May 2017

Accepted after revision: 23 June 2017

Publication Date:
21 July 2017 (eFirst)


A metal-free synthesis of isatins was achieved through the oxidative reactions of oxindoles with molecular oxygen in the presence of tert-butyl nitrite as an additive. This strategy provides a convenient and simple synthetic route to the construction of C=O bonds without the need for any catalyst or base. The attractive features of this reaction include its convenient procedure and mild reaction conditions.

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