DOI: 10.1055/s-0036-1590980
© Georg Thieme Verlag Stuttgart · New York

An Approach to the Diastereoselective Synthesis of Cyclohexane-1,3-dicarboxamide Derivatives via a Pseudo Five-Component ­Reaction Based on Diketene

Bahareh Talaei, Majid M. Heravi*, Hossein A. Oskooie, Atieh Rezvanian
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Publication History

Received: 01 July 2017

Accepted after revision: 06 September 2017

Publication Date:
19 September 2017 (eFirst)


A one-pot pseudo five-component reaction for the synthesis of 2-aryl-4-hydroxy-4-methyl-6-oxo-N 1,N 3-dialkylcyclohexane-1,3-dicarboxamide derivatives involving different primary amines, various aromatic aldehydes, and diketene in the presence of triethylamine with high yields is achieved.

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