Synthesis 2018; 50(16): 3243-3249
DOI: 10.1055/s-0036-1591589
paper
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Indolo[2,1-a]isoquinolines via Copper-Catalyzed C–C Coupling and Cyclization of 2-(2-Bromoaryl)-1H-indoles with 1,3-Diketones

Ha Kyeong Lee
a   Department of Applied Chemistry, Kyungpook National University, 80 Daehakro, Bukgu, Daegu 41566, Republic of Korea   Email: cscho@knu.ac.kr
,
Pham Duy Quang Dao
a   Department of Applied Chemistry, Kyungpook National University, 80 Daehakro, Bukgu, Daegu 41566, Republic of Korea   Email: cscho@knu.ac.kr
,
Young-su Kim
b   School of Hotel Culinary, Kyungdong University, Sokcho 217-711, Republic of Korea
,
Chan Sik Cho*
a   Department of Applied Chemistry, Kyungpook National University, 80 Daehakro, Bukgu, Daegu 41566, Republic of Korea   Email: cscho@knu.ac.kr
› Author Affiliations
This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2017R1D1A1B03028226). P.D.Q.D. thanks Y. M. Park, Internal Medicine of Geoje Medical Center (Gyeongnam, Republic of Korea) for partial financial support during his stay in the Republic of Korea.
Further Information

Publication History

Received: 23 March 2018

Accepted after revision: 23 April 2018

Publication Date:
12 June 2018 (online)


Abstract

2-(2-Bromoaryl)-1H-indoles are coupled and cyclized with 1,3-diketones by microwave irradiation in DMF in the presence of a catalytic amount of copper(I) iodide along with a base to afford the corresponding indolo[2,1-a]isoquinolines in moderate to good yields.

Supporting Information

 
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