Comparison of Two Reagents for Thionations

Abstract

Pyridine reacts readily with P₄S₁₀ to form a reagent with the composition C₁₀H₁₀N₂P₂S₅ that is useful for thionations of amides. The thionating properties of this reagent are compared with those of Lawesson’s reagent.

1 Introduction

2 Development of C₁₀H₁₀N₂P₂S₅

3 Use of Thionation for Modification of Biologically Active Compounds

3.1 Thionations of Peptides

3.2 Thionated Compounds of Interest as Potential Antivirals

3.3 Thionations of Thalidomide and Related Molecules

4 Comparison of Lawesson’s Reagent and C₁₀H₁₀N₂P₂S₅

Key words

thionation - P₄S₁₀ - Lawesson’s reagent - biologically active compounds - antivirals

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