Neurological Manifestations in Familial Mediterranean Fever: Results of 22 Children from a Reference Center in Kayseri, an Urban Area in Central Anatolia, Turkey

Mehmet Canpolat; Hakan Gumus; Zubeyde Gunduz; Ruhan Dusunsel; Sefer Kumandas; Ayşe Kaçar Bayram; Sibel Yel; Hatice Gamze Poyrazoglu; Kenan Yilmaz; Selim Doganay; Ali Yikilmaz; Munis Dundar; Huseyin Per

doi:10.1055/s-0036-1593374

Neuropediatrics, Inhaltsverzeichnis

Neuropediatrics 2017; 48(02): 079-085
DOI: 10.1055/s-0036-1593374

Original Article

Georg Thieme Verlag KG Stuttgart · New York

Neurological Manifestations in Familial Mediterranean Fever: Results of 22 Children from a Reference Center in Kayseri, an Urban Area in Central Anatolia, Turkey

Autor*innen

Mehmet Canpolat

¹Division of Pediatric Neurology, Department of Pediatrics, Erciyes University, Faculty of Medicine, Kayseri, Turkey
Hakan Gumus

¹Division of Pediatric Neurology, Department of Pediatrics, Erciyes University, Faculty of Medicine, Kayseri, Turkey
Zubeyde Gunduz

²Division of Pediatric Nephrology and Rheumatology, Department of Pediatrics, Erciyes University, Faculty of Medicine, Kayseri, Turkey
Ruhan Dusunsel

²Division of Pediatric Nephrology and Rheumatology, Department of Pediatrics, Erciyes University, Faculty of Medicine, Kayseri, Turkey
Sefer Kumandas

¹Division of Pediatric Neurology, Department of Pediatrics, Erciyes University, Faculty of Medicine, Kayseri, Turkey
Ayşe Kaçar Bayram

¹Division of Pediatric Neurology, Department of Pediatrics, Erciyes University, Faculty of Medicine, Kayseri, Turkey
Sibel Yel

³Division of Pediatric Nephrology, Department of Pediatrics, Erciyes University, Faculty of Medicine, Kayseri, Turkey
Hatice Gamze Poyrazoglu

¹Division of Pediatric Neurology, Department of Pediatrics, Erciyes University, Faculty of Medicine, Kayseri, Turkey
Kenan Yilmaz

³Division of Pediatric Nephrology, Department of Pediatrics, Erciyes University, Faculty of Medicine, Kayseri, Turkey
Selim Doganay

⁴Department of Radiology and Pediatric Radiology, Erciyes University, Faculty of Medicine, Kayseri, Turkey
Ali Yikilmaz

⁴Department of Radiology and Pediatric Radiology, Erciyes University, Faculty of Medicine, Kayseri, Turkey
Munis Dundar

⁵Department of Medical Genetics, Erciyes University, Faculty of Medicine, Kayseri, Turkey
Huseyin Per

¹Division of Pediatric Neurology, Department of Pediatrics, Erciyes University, Faculty of Medicine, Kayseri, Turkey

Abstract

Background Familial Mediterranean fever (FMF) is an inherited inflammatory disorder characterized by attacks of fever with polyserositis.

Objective The purpose of this study was to evaluate pediatric patients with FMF who had central nervous system (CNS) findings.

Materials and Methods Our medical records database for 2003 to 2014 was screened retrospectively. In total, 104 patients with FMF were identified, 22 of whom had undergone neurological examination for CNS symptoms.

Results Neurological findings included headache in 16 patients (72.7%), epilepsy in 6 patients (27.3%), pseudotumor cerebri in 2 patients (9.1%), multiple sclerosis in 1 patient (4.5%), and tremor in 1 patient (4.5%). The most common MEFV gene mutation was homozygous M694V (40.9%).

Conclusions Patients with FMF can present with various CNS manifestations. Further studies that include large populations are needed to elucidate the neurological manifestations of FMF.

Keywords

familial Mediterranean fever - neurological manifestations - M694V mutation - children

Volltext

Referenzen

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