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Neuropediatrics 2017; 48(01): 030-035
DOI: 10.1055/s-0036-1593611
Original Article
Georg Thieme Verlag KG Stuttgart · New York

Sleep Disturbances in Children with Rolandic Epilepsy

Maria Gogou
1   2nd Department of Pediatrics, School of Medicine, Aristotle University of Thessaloniki, University General Hospital AHEPA, Thessaloniki, Greece
,
Katerina Haidopoulou
2   4th Department of Pediatrics, School of Medicine, Aristotle University of Thessaloniki, General Hospital Papageorgiou, Thessaloniki, Greece
,
Maria Eboriadou
2   4th Department of Pediatrics, School of Medicine, Aristotle University of Thessaloniki, General Hospital Papageorgiou, Thessaloniki, Greece
,
Evangelos Pavlou
1   2nd Department of Pediatrics, School of Medicine, Aristotle University of Thessaloniki, University General Hospital AHEPA, Thessaloniki, Greece
› Author Affiliations
Further Information

Publication History

06 May 2016

04 September 2016

Publication Date:
25 October 2016 (online)

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Abstract

Background The aim of this study is to investigate through polysomnography sleep quality in children with rolandic epilepsy and compare sleep variables between these children and healthy controls.

Methods Our study population included 15 children with rolandic epilepsy and 27 healthy children who underwent overnight polysomnography. Parameters about sleep architecture and sleep respiratory events were recorded and analyzed. The level of statistical significance was set at 0.05.

Results Patients and controls did not differ in basic epidemiological traits. The percentage of sleep stage rapid eye movement was significantly lower in the epilepsy group. Moreover, the mean value of the obstructive apnea index and the obstructive apnea–hypopnea index was significantly higher in children with rolandic epilepsy compared with healthy children. Longest apnea duration and basal Spo 2 during sleep had also the trend to be higher and lower, respectively, in children with epilepsy.

Conclusions Children with rolandic epilepsy exhibit alterations in sleep architecture, as well as in sleep respiratory patterns. Therefore, sleep quality should be routinely considered in the long-term follow-up of these children.

Keywords

rolandic epilepsy - sleep disorders - children - polysomnography

Note

The work was performed in the 2nd Department of Pediatrics, University General Hospital AHEPA, Thessaloniki, Greece.


 

  • References

  • 1 Panayiotopoulos CP, Michael M, Sanders S, Valeta T, Koutroumanidis M. Benign childhood focal epilepsies: assessment of established and newly recognized syndromes. Brain 2008; 131 (Pt 9): 2264-2286
    CrossrefPubMedGoogle Scholar
  • 2 Iannetti P, Raucci U, Basile LA , et al. Benign epilepsy of childhood with centrotemporal spikes and unilateral developmental opercular dysplasia. Childs Nerv Syst 1994; 10 (4) 264-269
    CrossrefPubMedGoogle Scholar
  • 3 Northcott E, Connolly AM, Berroya A , et al. Memory and phonological awareness in children with Benign Rolandic Epilepsy compared to a matched control group. Epilepsy Res 2007; 75 (1) 57-62
    CrossrefPubMedGoogle Scholar
  • 4 Verrotti A, D'Egidio C, Agostinelli S, Parisi P, Chiarelli F, Coppola G. Cognitive and linguistic abnormalities in benign childhood epilepsy with centrotemporal spikes. Acta Paediatr 2011; 100 (5) 768-772
    CrossrefPubMedGoogle Scholar
  • 5 Parisi P, Matricardi S, Tozzi E, Sechi E, Martini C, Verrotti A. Benign epilepsy of childhood with centro-temporal spikes (BECTS) versus migraine: a neuropsychological assessment. Childs Nerv Syst 2012; 28 (12) 2129-2135
    CrossrefPubMedGoogle Scholar
  • 6 Cerminara C, D'Agati E, Lange KW , et al. Benign childhood epilepsy with centrotemporal spikes and the multicomponent model of attention: a matched control study. Epilepsy Behav 2010; 19 (1) 69-77
    CrossrefPubMedGoogle Scholar
  • 7 Chan S, Baldeweg T, Cross JH. A role for sleep disruption in cognitive impairment in children with epilepsy. Epilepsy Behav 2011; 20 (3) 435-440
    CrossrefPubMedGoogle Scholar
  • 8 Parisi P, Bruni O, Pia Villa M , et al. The relationship between sleep and epilepsy: the effect on cognitive functioning in children. Dev Med Child Neurol 2010; 52 (9) 805-810
    CrossrefPubMedGoogle Scholar
  • 9 Lerman P. Benign partial epilepsy with centro-temporal spikes. In: Roger J, Bureau M, Dravet C, , et al, eds. Epileptic Syndromes in Infancy, Childhood and Adolescence. 2nd ed. London, United Kingdom: John Libbey; 1992: 189-200
    Google Scholar
  • 10 Engel Jr J. Report of the ILAE classification core group. Epilepsia 2006; 47 (9) 1558-1568
    CrossrefPubMedGoogle Scholar
  • 11 Iber C, Ancoli-Israel S, Chesson Jr AL, Quan SF. The AASM Manual for the Scoring of Sleep and Associated Events: Rules, Terminology and Technical Specifications. Darien, IL: American Academy of Sleep Medicine; 2007: 47-48
    Google Scholar
  • 12 Marcus CL, Brooks LJ, Draper KA , et al. Diagnosis and management of childhood obstructive sleep apnea syndrome. Pediatrics 2012; 130: 714-755
    CrossrefPubMedGoogle Scholar
  • 13 Maganti R, Sheth RD, Hermann BP, Weber S, Gidal BE, Fine J. Sleep architecture in children with idiopathic generalized epilepsy. Epilepsia 2005; 46 (1) 104-109
    CrossrefPubMedGoogle Scholar
  • 14 Kaleyias J, Cruz M, Goraya JS , et al. Spectrum of polysomnographic abnormalities in children with epilepsy. Pediatr Neurol 2008; 39 (3) 170-176
    CrossrefPubMedGoogle Scholar
  • 15 Nunes ML, Ferri R, Arzimanoglou A, Curzi L, Appel CC, Costa da Costa J. Sleep organization in children with partial refractory epilepsy. J Child Neurol 2003; 18 (11) 763-766
    CrossrefPubMedGoogle Scholar
  • 16 Miano S, Bruni O, Aricò D, Elia M, Ferri R. Polysomnographic assessment of sleep disturbances in children with developmental disabilities and seizures. Neurol Sci 2010; 31 (5) 575-583
    CrossrefPubMedGoogle Scholar
  • 17 Eisensehr I, Parrino L, Noachtar S, Smerieri A, Terzano MG. Sleep in Lennox-Gastaut syndrome: the role of the cyclic alternating pattern (CAP) in the gate control of clinical seizures and generalized polyspikes. Epilepsy Res 2001; 46 (3) 241-250
    CrossrefPubMedGoogle Scholar
  • 18 Jain SV, Horn PS, Simakajornboon N, Glauser TA. Obstructive sleep apnea and primary snoring in children with epilepsy. J Child Neurol 2013; 28 (1) 77-82
    CrossrefPubMedGoogle Scholar
  • 19 Becker DA, Fennell EB, Carney PR. Daytime behavior and sleep disturbance in childhood epilepsy. Epilepsy Behav 2004; 5 (5) 708-715
    CrossrefPubMedGoogle Scholar
  • 20 Becker DA, Fennell EB, Carney PR. Sleep disturbance in children with epilepsy. Epilepsy Behav 2003; 4 (6) 651-658
    CrossrefPubMedGoogle Scholar
  • 21 Bruni O, Novelli L, Luchetti A , et al. Reduced NREM sleep instability in benign childhood epilepsy with centro-temporal spikes. Clin Neurophysiol 2010; 121 (5) 665-671
    CrossrefPubMedGoogle Scholar
  • 22 Pereira AM, Bruni O, Ferri R, Palmini A, Nunes ML. The impact of epilepsy on sleep architecture during childhood. Epilepsia 2012; 53 (9) 1519-1525
    CrossrefPubMedGoogle Scholar
  • 23 Carotenuto M, Parisi P, Esposito M, Cortese S, Elia M. Sleep alterations in children with refractory epileptic encephalopathies: a polysomnographic study. Epilepsy Behav 2014; 35: 50-53
    CrossrefPubMedGoogle Scholar
  • 24 Matos G, Tufik S, Scorza FA, Cavalheiro EA, Andersen ML. Sleep and epilepsy: exploring an intriguing relationship with a translational approach. Epilepsy Behav 2013; 26 (3) 405-409
    CrossrefPubMedGoogle Scholar
  • 25 Parisi P. News on the horizon is not good: interictal epileptic discharges continue to be unaffected by the therapeutic level of AEDs. Epilepsia 2010; 51 (5) 933-934
    CrossrefPubMedGoogle Scholar
  • 26 Samaitienė R, Norkūnienė J, Tumienė B, Grikinienė J. Sleep and behavioral problems in rolandic epilepsy. Pediatr Neurol 2013; 48 (2) 115-122
    CrossrefPubMedGoogle Scholar
  • 27 Maganti R, Hausman N, Koehn M, Sandok E, Glurich I, Mukesh BN. Excessive daytime sleepiness and sleep complaints among children with epilepsy. Epilepsy Behav 2006; 8 (1) 272-277
    CrossrefPubMedGoogle Scholar
  • 28 Ong LC, Yang WW, Wong SW, alSiddiq F, Khu YS. Sleep habits and disturbances in Malaysian children with epilepsy. J Paediatr Child Health 2010; 46 (3) 80-84
    CrossrefPubMedGoogle Scholar
  • 29 Derry CP, Duncan S. Sleep and epilepsy. Epilepsy Behav 2013; 26 (3) 394-404
    CrossrefPubMedGoogle Scholar
  • 30 Bonanni E, Massetani R, Galli R , et al. A quantitative study of daytime sleepiness induced by carbamazepine and add-on vigabatrin in epileptic patients. Acta Neurol Scand 1997; 95 (4) 193-196
    CrossrefPubMedGoogle Scholar
  • 31 Legros B, Bazil CW. Effects of antiepileptic drugs on sleep architecture: a pilot study. Sleep Med 2003; 4 (1) 51-55
    CrossrefPubMedGoogle Scholar
  • 32 Jain SV, Horn PS, Simakajornboon N , et al. Melatonin improves sleep in children with epilepsy: a randomized, double-blind, crossover study. Sleep Med 2015; 16 (5) 637-644
    CrossrefPubMedGoogle Scholar
  • 33 Jain SV, Simakajornboon N, Glauser TA. Provider practices impact adequate diagnosis of sleep disorders in children with epilepsy. J Child Neurol 2013; 28 (5) 589-595
    CrossrefPubMedGoogle Scholar
  • 34 Goh DY, Galster P, Marcus CL. Sleep architecture and respiratory disturbances in children with obstructive sleep apnea. Am J Respir Crit Care Med 2000; 162 (2 Pt 1): 682-686
    CrossrefPubMedGoogle Scholar
  • 35 Jain SV, Simakajornboon S, Shapiro SM, Morton LD, Leszczyszyn DJ, Simakajornboon N. Obstructive sleep apnea in children with epilepsy: prospective pilot trial. Acta Neurol Scand 2012; 125 (1) e3-e6
    CrossrefPubMedGoogle Scholar
  • 36 St-John WM, Rudkin AH, Homes GL, Leiter JC. Changes in respiratory-modulated neural activities, consistent with obstructive and central apnea, during fictive seizures in an in situ anaesthetized rat preparation. Epilepsy Res 2006; 70 (2–3): 218-228
    PubMedGoogle Scholar
  • 37 Terndrup TE, Darnall R, Knuth SL, Bartlett Jr D. Effects of experimental cortical seizures on respiratory motor nerve activities in piglets. J Appl Physiol (1985) 1999; 86 (6) 2052-2058
    CrossrefPubMedGoogle Scholar
  • 38 Gogou M, Haidopoulou K, Eboriadou M, Pavlou E. Sleep apneas and epilepsy comorbidity in childhood: a systematic review of the literature. Sleep Breath 2015; 19 (2) 421-432
    CrossrefPubMedGoogle Scholar
  • 39 Kanemura H, Sano F, Maeda Y, Sugita K, Aihara M. Valproate sodium enhances body weight gain in patients with childhood epilepsy: a pathogenic mechanisms and open-label clinical trial of behavior therapy. Seizure 2012; 21 (7) 496-500
    CrossrefPubMedGoogle Scholar
  • 40 Verrotti A, Laus M, Scardapane A, Franzoni E, Chiarelli F. Thyroid hormones in children with epilepsy during long-term administration of carbamazepine and valproate. Eur J Endocrinol 2009; 160 (1) 81-86
    CrossrefPubMedGoogle Scholar
  • 41 Bertorelli R, Ferri N, Adami M, Ongini E. Effects of four antiepileptic drugs on sleep and waking in the rat under both light and dark phases. Pharmacol Biochem Behav 1996; 53 (3) 559-565
    CrossrefPubMedGoogle Scholar
  • 42 Segal E, Vendrame M, Gregas M, Loddenkemper T, Kothare SV. Effect of treatment of obstructive sleep apnea on seizure outcomes in children with epilepsy. Pediatr Neurol 2012; 46 (6) 359-362
    CrossrefPubMedGoogle Scholar
  • 43 Zanzmera P, Shukla G, Gupta A , et al. Effect of successful epilepsy surgery on subjective and objective sleep parameters--a prospective study. Sleep Med 2013; 14 (4) 333-338
    CrossrefPubMedGoogle Scholar
  • 44 Cortesi F, Giannotti F, Ottaviano S. Sleep problems and daytime behavior in childhood idiopathic epilepsy. Epilepsia 1999; 40 (11) 1557-1565
    CrossrefPubMedGoogle Scholar
  • 45 Tang SS, Clarke T, Owens J, Pal DK. Sleep behavior disturbances in rolandic epilepsy. J Child Neurol 2011; 26 (2) 239-243
    CrossrefPubMedGoogle Scholar
  • 46 Scholle S, Scholle HC, Kemper A , et al. First night effect in children and adolescents undergoing polysomnography for sleep-disordered breathing. Clin Neurophysiol 2003; 114 (11) 2138-2145
    CrossrefPubMedGoogle Scholar