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Synthesis 2018; 50(14): 2775-2783
DOI: 10.1055/s-0036-1609845
DOI: 10.1055/s-0036-1609845
paper
A Highly Efficient Copper(II)-Catalyzed Cross-Dehydrogenative-Coupling Reaction of N-Arylglycine Esters with 2-Arylimidazo[1,2-a]pyridines
Financial support from the National Natural Science Foundation of China (21602027, 11765003), the Natural Science Foundation of Jiangxi Province (20171BAB213006, 20171BAB203004), the China Postdoctoral Science Foundation (2018M632595), the Foundation of Jiangxi Educational Committee (GJJ170430) and the Scientific Research Foundation of East China University of Technology (DHBK2016112) are gratefully acknowledged.Further Information
Publication History
Received: 06 February 2018
Accepted after revision: 08 April 2018
Publication Date:
28 May 2018 (online)
Abstract
A rapid and highly efficient copper(II)-catalyzed cross-dehydrogenative coupling (CDC) reaction of N-arylglycine esters with imidazo[1,2-a]pyridines has been described. A broad range of N-arylglycine esters underwent the CDC reaction smoothly with 2-arylimidazo[1,2-a]pyridines to give α-substituted α-amino acid esters in excellent yields. This synthetic method has the advantages of high yields, good functional groups compatibility, simple operation, and mild reaction conditions. A possible mechanism for the CDC reaction is also proposed. The use of a copper salt as the catalyst and air as the terminal oxidant makes this transformation sustainable and practical.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1609845.
- Supporting Information
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