Eur J Pediatr Surg 2017; 27(06): 516-525
DOI: 10.1055/s-0037-1598250
Original Article
Georg Thieme Verlag KG Stuttgart · New York

Surgical Management of Congenital Abdominal Wall Defects in Germany: A Population-Based Study and Comparison with Literature Reports

Carmen Dingemann
1   Department of Pediatric Surgery, Hannover Medical School, Hannover, Germany
,
Janine Dietrich
2   Center for Health Economics Research Hannover (CHERH), Leibniz University Hannover, Hannover, Germany
,
Jan Zeidler
2   Center for Health Economics Research Hannover (CHERH), Leibniz University Hannover, Hannover, Germany
,
Jochen Blaser
3   Representative Office of Lower Saxony, Techniker Krankenkasse (Health Insurance), Hannover, Germany
,
Jan Hendrik Gosemann
1   Department of Pediatric Surgery, Hannover Medical School, Hannover, Germany
4   Department of Pediatric Surgery, University of Leipzig, Leipzig, Germany
,
Martin Lacher
1   Department of Pediatric Surgery, Hannover Medical School, Hannover, Germany
4   Department of Pediatric Surgery, University of Leipzig, Leipzig, Germany
,
Benno Ure
1   Department of Pediatric Surgery, Hannover Medical School, Hannover, Germany
› Author Affiliations
Further Information

Publication History

05 April 2016

22 December 2016

Publication Date:
24 February 2017 (online)

Abstract

Introduction We aimed to analyze for the first time the characteristics, treatment modalities, and outcomes in infants with congenital abdominal wall defects (CAWDs) in Germany and to compare the results with current literature reports.

Patients and Methods Data of a health insurance covering approximately 10% of the German population were analyzed. Patients who had undergone CAWD closure during a period of nearly 6 years were included. Surgical approach was categorized into primary versus secondary closure. Complications were defined as any reintervention within 1 year after initial treatment.

Results Patients with gastroschisis were treated in 24 centers, newborns with omphalocele in 34 centers. There was no mortality, and the type of surgical approach had no significant impact on the incidence of complications in both gastroschisis and omphalocele. Out of 39 patients with gastroschisis, 72% had undergone primary closure being associated with a shorter duration of ventilation (p = 0.003) and hospitalization (p < 0.001). Out of 54 patients with omphalocele, 54% had undergone secondary closure, whereas modality of management did not affect duration of ventilation and hospitalization. Although heterogeneous, data of the current literature were comparable to those of this study.

Conclusion Unbiased data demonstrate for the first time that the quality of the current surgical management of newborns with CAWD across Germany is excellent. There was no correlation of complications with the method of closure in gastroschisis and omphalocele.

Funding

None.


 
  • References

  • 1 Blazer S, Zimmer EZ, Gover A, Bronshtein M. Fetal omphalocele detected early in pregnancy: associated anomalies and outcomes. Radiology 2004; 232 (01) 191-195
  • 2 Laughon M, Meyer R, Bose C. , et al. Rising birth prevalence of gastroschisis. J Perinatol 2003; 23 (04) 291-293
  • 3 Kilby MD. The incidence of gastroschisis. BMJ 2006; 332 (7536): 250-251
  • 4 Weber TR, Au-Fliegner M, Downard CD, Fishman SJ. Abdominal wall defects. Curr Opin Pediatr 2002; 14 (04) 491-497
  • 5 Wilson RD, Johnson MP. Congenital abdominal wall defects: an update. Fetal Diagn Ther 2004; 19 (05) 385-398
  • 6 Gamba P, Midrio P. Abdominal wall defects: prenatal diagnosis, newborn management, and long-term outcomes. Semin Pediatr Surg 2014; 23 (05) 283-290
  • 7 Christison-Lagay ER, Kelleher CM, Langer JC. Neonatal abdominal wall defects. Semin Fetal Neonatal Med 2011; 16 (03) 164-172
  • 8 Frolov P, Alali J, Klein MD. Clinical risk factors for gastroschisis and omphalocele in humans: a review of the literature. Pediatr Surg Int 2010; 26 (12) 1135-1148
  • 9 Tunell WP, Puffinbarger NK, Tuggle DW, Taylor DV, Mantor PC. Abdominal wall defects in infants. Survival and implications for adult life. Ann Surg 1995; 221 (05) 525-528
  • 10 Koivusalo A, Lindahl H, Rintala RJ. Morbidity and quality of life in adult patients with a congenital abdominal wall defect: a questionnaire survey. J Pediatr Surg 2002; 37 (11) 1594-1601
  • 11 Owen A, Marven S, Johnson P. , et al; BAPS-CASS. Gastroschisis: a national cohort study to describe contemporary surgical strategies and outcomes. J Pediatr Surg 2010; 45 (09) 1808-1816
  • 12 Kaiser MM, Kahl F, von Schwabe C, Halsband H. Omphalocele and gastroschisis. Outcome--complications--follow-up-quality of life [in German]. Chirurg 2000; 71 (10) 1256-1262
  • 13 Marven S, Owen A. Contemporary postnatal surgical management strategies for congenital abdominal wall defects. Semin Pediatr Surg 2008; 17 (04) 222-235
  • 14 Bianchi A, Dickson AP. Elective delayed reduction and no anesthesia: ‘minimal intervention management’ for gastrochisis. J Pediatr Surg 1998; 33 (09) 1338-1340
  • 15 Owen A, Marven S, Jackson L. , et al. Experience of bedside preformed silo staged reduction and closure for gastroschisis. J Pediatr Surg 2006; 41 (11) 1830-1835
  • 16 Pastor AC, Phillips JD, Fenton SJ. , et al. Routine use of a SILASTIC spring-loaded silo for infants with gastroschisis: a multicenter randomized controlled trial. J Pediatr Surg 2008; 43 (10) 1807-1812
  • 17 Krause H, Pötzsch S, Hass HJ. , et al. Congenital abdominal wall defects--an analysis of prevalence and operative management by means of gastroschisis and omphalocele [in German]. Zentralbl Chir 2009; 134 (06) 524-531
  • 18 Mortellaro VE, St Peter SD, Fike FB, Islam S. Review of the evidence on the closure of abdominal wall defects. Pediatr Surg Int 2011; 27 (04) 391-397
  • 19 Davies MW, Kimble RM, Woodgate PG. Ward reduction without general anaesthesia versus reduction and repair under general anaesthesia for gastroschisis in newborn infants. Cochrane Database Syst Rev 2002; (03) CD003671
  • 20 Weinsheimer RL, Yanchar NL, Bouchard SB. , et al; Canadian Pediatric Surgery Network. Gastroschisis closure--does method really matter?. J Pediatr Surg 2008; 43 (05) 874-878
  • 21 van Eijck FC, Wijnen RM, van Goor H. The incidence and morbidity of adhesions after treatment of neonates with gastroschisis and omphalocele: a 30-year review. J Pediatr Surg 2008; 43 (03) 479-483
  • 22 Henrich K, Huemmer HP, Reingruber B, Weber PG. Gastroschisis and omphalocele: treatments and long-term outcomes. Pediatr Surg Int 2008; 24 (02) 167-173
  • 23 Maksoud-Filho JG, Tannuri U, da Silva MM, Maksoud JG. The outcome of newborns with abdominal wall defects according to the method of abdominal closure: the experience of a single center. Pediatr Surg Int 2006; 22 (06) 503-507
  • 24 Driver CP, Bowen J, Doig CM, Bianchi A, Dickson AP, Bruce J. The influence of delay in closure of the abdominal wall on outcome in gastroschisis. Pediatr Surg Int 2001; 17 (01) 32-34
  • 25 Nüllen H, Müller E, Schütter FW. Complications and survival rate following operations for omphalocele and gastroschisis (author's transl) . [in German]. Z Kinderchir Grenzgeb 1980; 30 (01) 41-45
  • 26 Fuchs J, Bolte O, Schmedding A, Bürger D, Mühlhaus K, Glüer S. Experiences with primary fascia closure of the abdomen in gastroschisis--a 16.  year review [in German]. Zentralbl Gynakol 1997; 119 (11) 554-559
  • 27 van Tuil C, Saxena AK, Willital GH. Experience with management of anterior abdominal wall defects using bovine pericard. Hernia 2006; 10 (01) 41-47
  • 28 Allotey J, Davenport M, Njere I. , et al. Benefit of preformed silos in the management of gastroschisis. Pediatr Surg Int 2007; 23 (11) 1065-1069
  • 29 Banyard D, Ramones T, Phillips SE, Leys CM, Rauth T, Yang EY. Method to our madness: an 18-year retrospective analysis on gastroschisis closure. J Pediatr Surg 2010; 45 (03) 579-584
  • 30 Rao SC, Pirie S, Minutillo C, Gollow I, Dickinson JE, Jacoby P. Ward reduction of gastroschisis in a single stage without general anaesthesia may increase the risk of short-term morbidities: results of a retrospective audit. J Paediatr Child Health 2009; 45 (06) 384-388
  • 31 Rijhwani A, Davenport M, Dawrant M. , et al. Definitive surgical management of antenatally diagnosed exomphalos. J Pediatr Surg 2005; 40 (03) 516-522
  • 32 Suita S, Okamatsu T, Yamamoto T. , et al. Changing profile of abdominal wall defects in Japan: results of a national survey. J Pediatr Surg 2000; 35 (01) 66-71
  • 33 Barrett MJ, Kozdoba O, Al Assaf N, Gillick J, Mortell A, Foran A. The national incidence and outcomes of gastroschisis repairs. Ir Med J 2014; 107 (03) 83-85
  • 34 Benjamin B, Wilson GN. Anomalies associated with gastroschisis and omphalocele: analysis of 2825 cases from the Texas Birth Defects Registry. J Pediatr Surg 2014; 49 (04) 514-519
  • 35 Corey KM, Hornik CP, Laughon MM, McHutchison K, Clark RH, Smith PB. Frequency of anomalies and hospital outcomes in infants with gastroschisis and omphalocele. Early Hum Dev 2014; 90 (08) 421-424
  • 36 Bradnock TJ, Marven S, Owen A. , et al; BAPS-CASS. Gastroschisis: one year outcomes from national cohort study. BMJ 2011; 343: d6749
  • 37 Stanger J, Mohajerani N, Skarsgard ED. ; Canadian Pediatric Surgery Network (CAPSNet). Practice variation in gastroschisis: factors influencing closure technique. J Pediatr Surg 2014; 49 (05) 720-723
  • 38 Boutros J, Regier M, Skarsgard ED. ; Canadian Pediatric Surgery Network. Is timing everything? The influence of gestational age, birth weight, route, and intent of delivery on outcome in gastroschisis. J Pediatr Surg 2009; 44 (05) 912-917
  • 39 Lao OB, Larison C, Garrison MM, Waldhausen JH, Goldin AB. Outcomes in neonates with gastroschisis in U.S. children's hospitals. Am J Perinatol 2010; 27 (01) 97-101
  • 40 Skarsgard ED, Claydon J, Bouchard S. , et al; Canadian Pediatric Surgical Network. Canadian Pediatric Surgical Network: a population-based pediatric surgery network and database for analyzing surgical birth defects. The first 100 cases of gastroschisis. J Pediatr Surg 2008; 43 (01) 30-34
  • 41 Emami CN, Youssef F, Baird RJ, Laberge JM, Skarsgard ED, Puligandla PS. ; Canadian Pediatric Surgery Network (CAPSNet). A risk-stratified comparison of fascial versus flap closure techniques on the early outcomes of infants with gastroschisis. J Pediatr Surg 2015; 50 (01) 102-106
  • 42 Molik KA, Gingalewski CA, West KW. , et al. Gastroschisis: a plea for risk categorization. J Pediatr Surg 2001; 36 (01) 51-55
  • 43 Cowan KN, Puligandla PS, Laberge JM. , et al; Canadian Pediatric Surgery Network. The gastroschisis prognostic score: reliable outcome prediction in gastroschisis. J Pediatr Surg 2012; 47 (06) 1111-1117
  • 44 Chang DC, Salazar-Osuna JH, Choo SS, Arnold MA, Colombani PM, Abdullah F. Benchmarking the quality of care of infants with low-risk gastroschisis using a novel risk stratification index. Surgery 2010; 147 (06) 766-771
  • 45 Lausman AY, Langer JC, Tai M. , et al. Gastroschisis: what is the average gestational age of spontaneous delivery?. J Pediatr Surg 2007; 42 (11) 1816-1821
  • 46 Langer JC. Abdominal wall defects. World J Surg 2003; 27 (01) 117-124
  • 47 Edwards EA, Broome S, Green S. , et al. Long-term respiratory support in children with giant omphalocele. Anaesth Intensive Care 2007; 35 (01) 94-98
  • 48 Gorra AS, Needelman H, Azarow KS, Roberts HJ, Jackson BJ, Cusick RA. Long-term neurodevelopmental outcomes in children born with gastroschisis: the tiebreaker. J Pediatr Surg 2012; 47 (01) 125-129
  • 49 Kassa AM, Lilja HE. Predictors of postnatal outcome in neonates with gastroschisis. J Pediatr Surg 2011; 46 (11) 2108-2114
  • 50 Clark RH, Walker MW, Gauderer MW. Factors associated with mortality in neonates with gastroschisis. Eur J Pediatr Surg 2011; 21 (01) 21-24
  • 51 Gornall P. Management of intestinal atresia complicating gastroschisis. J Pediatr Surg 1989; 24 (06) 522-524
  • 52 Singh SJ, Fraser A, Leditschke JF. , et al. Gastroschisis: determinants of neonatal outcome. Pediatr Surg Int 2003; 19 (04) 260-265
  • 53 Ross AR, Eaton S, Zani A, Ade-Ajayi N, Pierro A, Hall NJ. The role of preformed silos in the management of infants with gastroschisis: a systematic review and meta-analysis. Pediatr Surg Int 2015; 31 (05) 473-483
  • 54 Bonnard A, Zamakhshary M, de Silva N, Gerstle JT. Non-operative management of gastroschisis: a case-matched study. Pediatr Surg Int 2008; 24 (07) 767-771
  • 55 Jensen AR, Waldhausen JH, Kim SS. The use of a spring-loaded silo for gastroschisis: impact on practice patterns and outcomes. Arch Surg 2009; 144 (06) 516-519
  • 56 Kunz SN, Tieder JS, Whitlock K, Jackson JC, Avansino JR. Primary fascial closure versus staged closure with silo in patients with gastroschisis: a meta-analysis. J Pediatr Surg 2013; 48 (04) 845-857
  • 57 McNamara WF, Hartin CW, Escobar MA, Lee YH. Outcome differences between gastroschisis repair methods. J Surg Res 2011; 165 (01) 19-24
  • 58 Pacilli M, Spitz L, Kiely EM, Curry J, Pierro A. Staged repair of giant omphalocele in the neonatal period. J Pediatr Surg 2005; 40 (05) 785-788
  • 59 van Eijck FC, Hoogeveen YL, van Weel C, Rieu PN, Wijnen RM. Minor and giant omphalocele: long-term outcomes and quality of life. J Pediatr Surg 2009; 44 (07) 1355-1359
  • 60 Mann S, Blinman TA, Douglas Wilson R. Prenatal and postnatal management of omphalocele. Prenat Diagn 2008; 28 (07) 626-632