Pneumologie 2017; 71(S 01): S1-S125
DOI: 10.1055/s-0037-1598284
Freie Vorträge – Sektion Allergologie und Immunologie
Freie Vorträge der Sektion Allergologie und Immunologie – Marco Idzko/Freiburg, Henrik Watz/Großhansdorf
Georg Thieme Verlag KG Stuttgart · New York

Local Effects on Airway Inflammation and Systemic Uptake of 5nm PEG-coated and Uncoated Gold Nanoparticles in Asthmatic Mice

A Omlor
1  Klinik für Innere Medizin V, Pneumologie, Allergologie, Beatmungs- und Umweltmedizin, Universitätsklinikum des Saarlandes
,
DD Le
1  Klinik für Innere Medizin V, Pneumologie, Allergologie, Beatmungs- und Umweltmedizin, Universitätsklinikum des Saarlandes
,
J Schlicker
1  Klinik für Innere Medizin V, Pneumologie, Allergologie, Beatmungs- und Umweltmedizin, Universitätsklinikum des Saarlandes
,
R Ewen
1  Klinik für Innere Medizin V, Pneumologie, Allergologie, Beatmungs- und Umweltmedizin, Universitätsklinikum des Saarlandes
,
S Heck
1  Klinik für Innere Medizin V, Pneumologie, Allergologie, Beatmungs- und Umweltmedizin, Universitätsklinikum des Saarlandes
,
A Kraegeloh
2  INM – Leibniz Institut für Neue Materialien
,
M Hannig
3  Klinik für Zahnerhaltung, Parodontologie und Präventive Zahnheilkunde, Universitätsklinikum des Saarlandes
,
C Hein
4  Anorganische Festkörperchemie, Universität des Saarlandes
,
R Kautenburger
4  Anorganische Festkörperchemie, Universität des Saarlandes
,
G Kickelbick
4  Anorganische Festkörperchemie, Universität des Saarlandes
,
R Bals
1  Klinik für Innere Medizin V, Pneumologie, Allergologie, Beatmungs- und Umweltmedizin, Universitätsklinikum des Saarlandes
,
J Nguyen
5  Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, Suny Buffalo
,
QT Dinh
1  Klinik für Innere Medizin V, Pneumologie, Allergologie, Beatmungs- und Umweltmedizin, Universitätsklinikum des Saarlandes
› Author Affiliations
Further Information

Publication History

Publication Date:
23 February 2017 (online)

 

Nanotechnology is showing promise in many medical applications such as drug delivery and hyperthermia. Nanoparticles administered to the respiratory tract cause local reactions and cross the blood-air barrier, thereby providing a means for easy systemic administration but also a potential source of toxicity. Little is known about how these effects are influenced by pre-existing airway diseases such as asthma. Here, BALB/c mice were treated according to the OVA asthma protocol to promote allergic airway inflammation. Dispersions of polyethylene glycol (PEG)-coated and uncoated 5nm gold nanoparticles were applied intranasally to asthma and control groups and (i) airway resistance and (ii) local tissue effects measured as primary endpoints. Further, nanoparticle uptake into extrapulmonary organs was quantified by inductively-coupled plasma mass spectrometry (ICP-MS). The asthmatic precondition increased nanoparticle uptake. Moreover, systemic uptake was higher for PEG-coated gold nanoparticles compared to the uncoated particles. Nanoparticles inhibited both inflammatory infiltrates and airway hyperreactivity, especially uncoated gold nanoparticles. Although the anti-inflammatory effects of gold nanoparticles might be of therapeutic benefit, systemic uptake and consequent adverse effects must be considered when designing and testing nanoparticle-based asthma therapies.