High prevalence of obstructive pulmonary diseases in patients with peripheral artery disease
23 February 2017 (online)
Prevalence of atherosclerosis is increased in chronic obstructive pulmonary disease (COPD). However little is known about the frequency of potential obstructive ventilatory disorders in patients with atherosclerotic artery disease. Therefore, the aim of our study was the examination of this issue.
49 patients with a diagnosed peripheral artery disease and the absence of lung disorders in the medical history underwent lung function tests and arterialised earlobe blood gas analyses. Additionally, demographic data and cardiovascular risk factors such as arterial hypertension, diabetes mellitus, hypercholesterolemia and nicotine abuse were assessed.
11 (group 1) out of 49 patients had a significantly decreased forced expiratory volume in one second (FEV1) (65.2 ± 4.7% predicted) compared to the remaining individuals (group 2; 99.0 ± 2.3% predicted). Residual volume (RV) and total airway resistance (Rtot) were relevantly higher in group 1 (145.2 ± 9.8% predicted, 115.0 ± 12.7% predicted, respectively) versus group 2 (121.5 ± 5.0% predicted, 80.3 ± 5.2% predicted, resp.). Moreover, partial pressure of oxygen (pO2) was significantly reduced in group 1 (66.9 ± 4.2 mmHg) in comparison with group 2 (75.3 ± 1.3 mmHg). Of note, sex, age, body mass index and the distribution of cardiovascular risk factors were similar in both groups.
Obstructive ventilatory disorders have been newly diagnosed in 22.4% of patients with peripheral artery disease. Therefore, pulmonary function screening tests should be considered in this patient population.