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DOI: 10.1055/s-0037-1600323
Repeated intravenous administration of gadobutrol does not lead to increased signal intensity on unenhanced T1-weighted images – a voxel-based whole brain analysis
Publication History
Publication Date:
23 March 2017 (online)
Zielsetzung:
To identify a possible association between repeated intravenous administration of gadobutrol and increased signal intensity in the gray and white matter using voxel-based whole brain analysis.
Material und Methodik:
Patients (n = 217) with clinically isolated syndrome underwent baseline brain magnetic resonance imaging and at least one annual follow-up examination with intravenous administration of 0.1 mmol/kg body weight of gadobutrol. Patients were assigned to different groups according to the number of follow-up examinations performed. Using the DARTEL normalization process, tissue templates for gray matter, white matter, and CSF were calculated for each group, as were gray matter-to-CSF and white matter-to-CSF ratios. Voxel-based whole brain analysis was used to calculate signal intensity of gray matter for each voxel in each group. The paired t-test was applied to test differences to baseline MRI for significance.
Ergebnisse:
No significant changes in signal intensity of gray and white matter were observed after up to five gadobutrol administrations. There was also no significant change in gray matter-to-CSF and gray matter-to-CSF ratios after repeated administration of gadobutrol.
Schlussfolgerungen:
Voxel-based whole brain analysis did not demonstrate increased signal intensity of GM and WM on unenhanced T1-weighted images after repeated gadobutrol administration.