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Clin Colon Rectal Surg 2018; 31(03): 161-167
DOI: 10.1055/s-0037-1602236
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Translational Research in Familial Colorectal Cancer Syndromes

Molly M. Ford
1   Division of Colon and Rectal Surgery, Department of General Surgery, Vanderbilt University Medical Center, Nashville, Tennessee
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Publication History

Publication Date:
01 May 2018 (online)

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Abstract

Growing knowledge of inherited colorectal cancer syndromes has led to better surveillance and better care of this subset of patients. The most well-known entities, including Lynch syndrome and familial adenomatous polyposis, are continually being studied and with the advent of more sophisticated genetic testing, additional genetic discoveries have been made in the field of inherited cancer. This article will summarize many of the updates to both the familiar and perhaps less familiar syndromes that can lead to inherited or early-onset colorectal cancer.

Keywords

familial colorectal cancer - Lynch syndrome - FAP - serrated polyposis - POLE/POLD1
 

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