PDF herunterladen
Facial Plast Surg 2017; 33(04): 437-443
DOI: 10.1055/s-0037-1604240
Rapid Communication
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Platelet-Rich Plasma for the Aesthetic Surgeon

Jordan P. Sand
1   Department of Head and Neck Surgery, University of California Los Angeles David Geffen School of Medicine, Los Angeles, California
,
Vishad Nabili
1   Department of Head and Neck Surgery, University of California Los Angeles David Geffen School of Medicine, Los Angeles, California
,
Amit Kochhar
2   Department of Otolaryngology–Head and Neck Surgery, Keck Medicine at USC, Los Angeles, California
,
Jeffrey Rawnsley
1   Department of Head and Neck Surgery, University of California Los Angeles David Geffen School of Medicine, Los Angeles, California
,
Gregory Keller
1   Department of Head and Neck Surgery, University of California Los Angeles David Geffen School of Medicine, Los Angeles, California
› Institutsangaben
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
28. Juli 2017 (online)

    Lizenzen und Reprints

Abstract

Platelet-rich plasma (PRP) is an autogenously harvested blood plasma containing concentrated levels of platelets and growth factors. PRP has been identified as a promising treatment for enhancing wound healing and has been used for decades in multiple medical specialties including cardiac surgery, oral surgery, ophthalmology, and orthopedic surgery. Growing evidence for multiple aesthetic surgery applications has recently been developed, particularly for hair restoration and skin rejuvenation. The goal of this article is to review the current medical literature on PRP and identify promising applications that may be integrated into a modern aesthetic surgery practice. The evidence for the use of PRP technology is rapidly expanding as a powerful therapy for select cosmetic surgery patients.

Keywords

platelet-rich plasma - hair restoration - aesthetic surgery
 

  • References

  • 1 Kang RS, Lee MK, Seth R, Keller GS. Platelet-rich plasma in cosmetic surgery. Int J Otorhinolaryngol Clin 2013; 5 (01) 24-28
    PubMedGoogle Scholar
  • 2 Babbush CA, Kevy SV, Jacobson MS. An in vitro and in vivo evaluation of autologous platelet concentrate in oral reconstruction. Implant Dent 2003; 12 (01) 24-34
    CrossrefPubMedGoogle Scholar
  • 3 Sclafani AP, Romo III T, Ukrainsky G. , et al. Modulation of wound response and soft tissue ingrowth in synthetic and allogeneic implants with platelet concentrate. Arch Facial Plast Surg 2005; 7 (03) 163-169
    CrossrefPubMedGoogle Scholar
  • 4 Bhanot S, Alex JC. Current applications of platelet gels in facial plastic surgery. Facial Plast Surg 2002; 18 (01) 27-33
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 5 Eppley BL, Woodell JE, Higgins J. Platelet quantification and growth factor analysis from platelet-rich plasma: implications for wound healing. Plast Reconstr Surg 2004; 114 (06) 1502-1508
    PubMedGoogle Scholar
  • 6 Kevy S, Jacobson M. Preparation of growth factors enriched autologous platelet gel. In: Proceedings of the 27th Annual Meeting of Service Biomaterials; April, 2001 ; St. Paul, MN
    PubMedGoogle Scholar
  • 7 Sclafani AP, McCormick SA. Induction of dermal collagenesis, angiogenesis, and adipogenesis in human skin by injection of platelet-rich fibrin matrix. Arch Facial Plast Surg 2012; 14 (02) 132-136
    CrossrefPubMedGoogle Scholar
  • 8 Sclafani AP. Safety, efficacy, and utility of platelet-rich fibrin matrix in facial plastic surgery. Arch Facial Plast Surg 2011; 13 (04) 247-251
    CrossrefPubMedGoogle Scholar
  • 9 Singh B, Goldberg LJ. Autologous platelet-rich plasma for the treatment of pattern hair loss. Am J Clin Dermatol 2016; 17 (04) 359-367
    CrossrefPubMedGoogle Scholar
  • 10 Takikawa M, Nakamura S, Nakamura S. , et al. Enhanced effect of platelet-rich plasma containing a new carrier on hair growth. Dermatol Surg 2011; 37 (12) 1721-1729
    CrossrefPubMedGoogle Scholar
  • 11 Cervelli V, Garcovich S, Bielli A. , et al. The effect of autologous activated platelet rich plasma (AA-PRP) injection on pattern hair loss: clinical and histomorphometric evaluation. BioMed Res Int 2014; 2014: 760709
    CrossrefPubMedGoogle Scholar
  • 12 Gkini MA, Kouskoukis AE, Tripsianis G, Rigopoulos D, Kouskoukis K. Study of platelet-rich plasma injections in the treatment of androgenetic alopecia through an one-year period. J Cutan Aesthet Surg 2014; 7 (04) 213-219
    CrossrefPubMedGoogle Scholar
  • 13 Singhal P, Agarwal S, Dhot PS, Sayal SK. Efficacy of platelet-rich plasma in treatment of androgenic alopecia. Asian J Transfus Sci 2015; 9 (02) 159-162
    CrossrefPubMedGoogle Scholar
  • 14 Betsi EE, Germain E, Kalbermatten DF. , et al. Platelet-rich plasma injection is effective and safe for the treatment of alopecia. Eur J Plast Surg 2013; 36: 407-412
    CrossrefPubMedGoogle Scholar
  • 15 Khatu SS, More YE, Gokhale NR, Chavhan DC, Bendsure N. Platelet-rich plasma in androgenic alopecia: myth or an effective tool. J Cutan Aesthet Surg 2014; 7 (02) 107-110
    CrossrefPubMedGoogle Scholar
  • 16 Schiavone G, Raskovic D, Greco J, Abeni D. Platelet-rich plasma for androgenetic alopecia: a pilot study. Dermatol Surg 2014; 40 (09) 1010-1019
    CrossrefPubMedGoogle Scholar
  • 17 Kang JS, Zheng Z, Choi MJ, Lee SH, Kim DY, Cho SB. The effect of CD34+ cell-containing autologous platelet-rich plasma injection on pattern hair loss: a preliminary study. J Eur Acad Dermatol Venereol 2014; 28 (01) 72-79
    CrossrefPubMedGoogle Scholar
  • 18 Sclafani AP. Platelet-rich fibrin matrix (PRFM) for androgenetic alopecia. Facial Plast Surg 2014; 30 (02) 219-224
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 19 Marwah M, Godse K, Patil S, Nadkarni N. Is there sufficient research data to use platelet-rich plasma in dermatology?. Int J Trichology 2014; 6 (01) 35-36
    CrossrefPubMedGoogle Scholar
  • 20 Gentile P, Garcovich S, Bielli A, Scioli MG, Orlandi A, Cervelli V. The effect of platelet-rich plasma in hair regrowth: a randomized placebo-controlled trial. Stem Cells Transl Med 2015; 4 (11) 1317-1323
    CrossrefPubMedGoogle Scholar
  • 21 Alves R, Grimalt R. Randomized placebo-controlled, double-blind, half-head study to assess the efficacy of platelet-rich plasma on the treatment of androgenetic alopecia. Dermatol Surg 2016; 42 (04) 491-497
    CrossrefPubMedGoogle Scholar
  • 22 Gupta AK, Carviel JL. Randomized placebo-controlled, double-blind, meta-analysis of efficacy of platelet-rich plasma therapy for androgenetic alopecia. J Dermatolog Treat 2016; 9: 1-4
    PubMedGoogle Scholar
  • 23 Puig CJ, Reese R, Peters M. Double- blind, placebo-controlled pilot study on the use of platelet-rich plasma in women with female androgenetic alopecia. Dermatol Surg 2016; 42 (11) 1243-1247
    CrossrefPubMedGoogle Scholar
  • 24 Mapar MA, Shahriari S, Haghighizadeh MH. Efficacy of platelet-rich plasma in the treatment of androgenetic (male-patterned) alopecia: A pilot randomized controlled trial. J Cosmet Laser Ther 2016; 18 (08) 452-455
    CrossrefPubMedGoogle Scholar
  • 25 Trink A, Sorbellini E, Bezzola P. , et al. A randomized, double-blind, placebo- and active-controlled, half-head study to evaluate the effects of platelet-rich plasma on alopecia areata. Br J Dermatol 2013; 169 (03) 690-694
    CrossrefPubMedGoogle Scholar
  • 26 Gupta AK, Carviel J. A mechanistic model of platelet-rich plasma treatment for androgenetic alopecia. Dermatol Surg 2016; 42 (12) 1335-1339
    CrossrefPubMedGoogle Scholar
  • 27 Asif M, Kanodia S, Singh K. Combined autologous platelet-rich plasma with microneedling verses microneedling with distilled water in the treatment of atrophic acne scars: a concurrent split-face study. J Cosmet Dermatol 2016; 15 (04) 434-443
    CrossrefPubMedGoogle Scholar
  • 28 Lee JW, Kim BJ, Kim MN, Mun SK. The efficacy of autologous platelet rich plasma combined with ablative carbon dioxide fractional resurfacing for acne scars: a simultaneous split-face trial. Dermatol Surg 2011; 37 (07) 931-938
    CrossrefPubMedGoogle Scholar
  • 29 Kim H, Gallo J. Evaluation of the effect of platelet-rich plasma on recovery after ablative fractional photothermolysis. JAMA Facial Plast Surg 2015; 17 (02) 97-102
    CrossrefPubMedGoogle Scholar
  • 30 Na JI, Choi JW, Choi HR. , et al. Rapid healing and reduced erythema after ablative fractional carbon dioxide laser resurfacing combined with the application of autologous platelet-rich plasma. Dermatol Surg 2011; 37 (04) 463-468
    CrossrefPubMedGoogle Scholar
  • 31 Shin MK, Lee JH, Lee SJ, Kim NI. Platelet-rich plasma combined with fractional laser therapy for skin rejuvenation. Dermatol Surg 2012; 38 (04) 623-630
    CrossrefPubMedGoogle Scholar
  • 32 Runels C. Vampire Facelift: The Secret Blood Method to Revive Youth & Restore Beauty. Fairhope, AL: CreateSpace Independent Publishing Platform; 2013
    Google Scholar
  • 33 Ulusal BG. Platelet-rich plasma and hyaluronic acid - an efficient biostimulation method for face rejuvenation. J Cosmet Dermatol 2017; 16 (01) 112-119
    CrossrefPubMedGoogle Scholar
  • 34 Sclafani AP, Azzi J. Platelet preparations for use in facial rejuvenation and wound healing: a critical review of current literature. Aesthetic Plast Surg 2015; 39 (04) 495-505
    CrossrefPubMedGoogle Scholar
  • 35 Elnehrawy NY, Ibrahim ZA, Eltoukhy AM, Nagy HM. Assessment of the efficacy and safety of single platelet-rich plasma injection on different types and grades of facial wrinkles. J Cosmet Dermatol 2017; 16 (01) 103-111
    CrossrefPubMedGoogle Scholar
  • 36 Kamakura T, Kataoka J, Maeda K. , et al. Platelet- rich plasma with basic fibroblast growth factor for treatment of wrinkles and depressed areas of the skin. Plast Reconstr Surg 2015; 136 (05) 931-939
    CrossrefPubMedGoogle Scholar
  • 37 Redaelli A, Romano D, Marcianó A. Face and neck revitalization with platelet-rich plasma (PRP): clinical outcome in a series of 23 consecutively treated patients. J Drugs Dermatol 2010; 9 (05) 466-472
    PubMedGoogle Scholar
  • 38 Marchac D, Sándor G. Face lifts and sprayed fibrin glue: an outcome analysis of 200 patients. Br J Plast Surg 1994; 47 (05) 306-309
    CrossrefPubMedGoogle Scholar
  • 39 Marchac D, Greensmith AL. Early postoperative efficacy of fibrin glue in face lifts: a prospective randomized trial. Plast Reconstr Surg 2005; 115 (03) 911-916 , discussion 917–918
    CrossrefPubMedGoogle Scholar
  • 40 Jones BM, Grover R. Avoiding hematoma in cervicofacial rhytidectomy: a personal 8-year quest. Reviewing 910 patients. Plast Reconstr Surg 2004; 113 (01) 381-387 , discussion 388–390
    CrossrefPubMedGoogle Scholar
  • 41 Farrior E, Ladner K. Platelet gels and hemostasis in facial plastic surgery. Facial Plast Surg 2011; 27 (04) 308-314
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 42 Costa CR, Ramanadham SR, O'Reilly E, Coleman JE, Rohrich RJ. The role of the superwet technique in face lift: an analysis of 1089 patients over 23 years. Plast Reconstr Surg 2015; 135 (06) 1566-1572
    CrossrefPubMedGoogle Scholar
  • 43 Salgarello M, Visconti G, Rusciani A. Breast fat grafting with platelet-rich plasma: a comparative clinical study and current state of the art. Plast Reconstr Surg 2011; 127 (06) 2176-2185
    CrossrefPubMedGoogle Scholar
  • 44 Serra-Mestre JM, Serra-Renom JM, Martinez L, Almadori A, D'Andrea F. Platelet-rich plasma mixed-fat grafting: a reasonable prosurvival strategy for fat grafts?. Aesthetic Plast Surg 2014; 38 (05) 1041-1049
    CrossrefPubMedGoogle Scholar
  • 45 Fontdevila J, Guisantes E, Martínez E, Prades E, Berenguer J. Double-blind clinical trial to compare autologous fat grafts versus autologous fat grafts with PDGF: no effect of PDGF. Plast Reconstr Surg 2014; 134 (02) 219e-230e
    CrossrefPubMedGoogle Scholar
  • 46 Cervelli V, Gentile P, Scioli MG. , et al. Application of platelet-rich plasma in plastic surgery: clinical and in vitro evaluation. Tissue Eng Part C Methods 2009; 15 (04) 625-634
    PubMedGoogle Scholar
  • 47 Azzena B, Mazzoleni F, Abatangelo G, Zavan B, Vindigni V. Autologous platelet-rich plasma as an adipocyte in vivo delivery system: case report. Aesthetic Plast Surg 2008; 32 (01) 155-158 , discussion 159–161
    CrossrefPubMedGoogle Scholar
  • 48 Miller JD, Rankin TM, Hua NT. , et al. Reduction of pain via platelet-rich plasma in split-thickness skin graft donor sites: a series of matched pairs. Diabet Foot Ankle 2015; 6: 24972
    PubMedGoogle Scholar