Planta Medica International Open 2017; 4(S 01): S1-S202
DOI: 10.1055/s-0037-1608065
Poster Session
Georg Thieme Verlag KG Stuttgart · New York

CYTOTOXIC ALKALOIDS FROM ROOTS OF GONIOTHALAMUS LANCEOLATUS (BÂN) MAT-SALLEH

H Ismail Nor
1   Atta-ur-Rahman Institute for Natural Products Discovery,Universiti Teknologi MARA, Selangor, Malaysia
,
E Rasol Nurulfazlina
1   Atta-ur-Rahman Institute for Natural Products Discovery,Universiti Teknologi MARA, Selangor, Malaysia
,
B Ahmad Fasihuddin
2   Department of Chemistry, Faculty of Resourse Science and Technology, Universiti Malaysia Sarawak, Sarawak, Malaysia
,
CW Mai
3   School of Pharmacy, International Medical University, Kuala Lumpur, Malaysia
› Author Affiliations
Further Information

Publication History

Publication Date:
24 October 2017 (online)

 

Goniothalamus lanceolatus (Bân) Mat-Salleh is an ethnomedicinal plant indigenous to Sarawak, Malaysia used as traditional remedy for cancer by the local people but has not been previously studied, chemically or biologically. Interestingly, comprehensive UHPLC-MS profiling of the root extract detects presence of alkaloidal components in addition to the well-known styryl lactones and acetogenins, usually present in Goniothalamus species. Evaluation of fractions obtained from the dichloromethane root extract showed cytotoxic activities against three panels of cancer cell lines, which are the human breast cell lines (MCF-7, MDA-MB-231 and MDA-MB-468), human colon cell lines (HT29, HCT116 and SW48) and lung cancer cell lines (A549, NCI-H23, and NCI-H1299). Guided by the cytotoxic activities, herein we report isolation of lactam alkaloid 1 and quinone alkaloid 2, together with a known styryl lactone, 9-deoxygoniopypyrone 3, from the roots G. lanceolatus. Compound 1 showed strong cytotoxic effect on human lung and human colon cancer cell lines with IC50 values ranging from 5.32 to 9.91µM.