Planta Medica International Open 2017; 4(S 01): S1-S202
DOI: 10.1055/s-0037-1608084
Poster Session
Georg Thieme Verlag KG Stuttgart · New York

The First Plant Seco-Steroid and a New lignan from the Australian Arid Zone

P Tan Yuen
1   University of Queensland, Brisbane, Australia
,
A Savchenko
1   University of Queensland, Brisbane, Australia
,
N Broit
2   QIMR Berghofer Medical Research Institute, Brisbane, Australia
,
G Boyle
2   QIMR Berghofer Medical Research Institute, Brisbane, Australia
,
P Parsons
2   QIMR Berghofer Medical Research Institute, Brisbane, Australia
,
C Williams
1   University of Queensland, Brisbane, Australia
› Author Affiliations
Further Information

Publication History

Publication Date:
24 October 2017 (online)

 

Terrestrial plants from Australia's arid zone and deserts have received little attention in terms of bioactive profiling and secondary metabolite discovery. The Australian desert shrub Frankenia foliosa and Eremophila macdonnellii from the Simpson Desert were chosen as a novel species for investigation. F. foliosa has revealed the first B-ring 5,6-seco-steroid (1) isolated from plant and displayed inhibitory activity against head and neck SCC cancer cell lines that contain the cdc25A phosphatase protein with IC50 =˜8.0µM. E. macdonnellii has isolated one new, and six known, furofuran lignans. The new lignan (2) displayed moderate anti-cancer activity against the breast cancer cell line (MCF-7) and hypopharyngeal cancer cell line (FaDu) with IC50 = 10.0µM and IC50 = 20µM, respectively.

[1] Tan Y.P, Savchenko A.I, Broit N, Boyle, G.M, Parsons, P.G, and Williams C. Eur. J. Org. Chem. 2017; 11:1498 – 1501.