Planta Medica International Open 2017; 4(S 01): S1-S202
DOI: 10.1055/s-0037-1608342
Poster Session
Georg Thieme Verlag KG Stuttgart · New York

Inhibition of alpha-glucosidase and lipase activities of Phyllanthus emblica and Alpinia galanga

C Chansriniyom
1   Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Phatumwan, Thailand
,
K Likhitwitayawuid
1   Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Phatumwan, Thailand
› Author Affiliations
Further Information

Publication History

Publication Date:
24 October 2017 (online)

 

Two culinary anti-hyperlipidemic herbs, Phyllanthus emblica fruits and Alpinia galanga rhizomes, were evaluated for inhibition of alpha-glucosidase and lipase activities. The activities were determined using 4-nitrophenol-α-D-glucopyranoside [1] and 4-methylumbelliferone oleate [2] as substrates for α-glucosidase and lipase, respectively. The ethanolic extracts of P. emblica and A. galanga exhibited stronger anti-α-glucosidase activities than acarbose (IC50 of 168.380 ± 1.227 µg/mL), a positive control, with IC50 values of 0.333 ± 0.001 and 14.059 ± 0.187 µg/mL, respectively. Regarding anti-lipase activity, A. galanga ethanolic extract (IC50 of 35.654 ± 0.656 µg/mL) showed stronger activity than P. emblica ethanolic extract (IC50 of 119.367 ± 2.075 µg/mL); however, these extracts were much less active than the drug orlistat (IC50 of 0.007 ± 0.000 µg/mL). These results suggest that ingestion of P. emblica fruits and A. galanga rhizomes is beneficial for anti-diabetes and anti-hyperlipidemia.

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[2] Duangjai A, Ingkaninan K, Limpeanchob N. Nat Prod Res 2011; 25: 341 – 352.