Planta Medica International Open 2017; 4(S 01): S1-S202
DOI: 10.1055/s-0037-1608531
Poster Session
Georg Thieme Verlag KG Stuttgart · New York

From ethnobotany to the laboratory: a computer aided ethnobotanic method for the identification of plants with interesting biological activities

NK Tittikpina
1   Faculty of Pharmacy, Department of Bio-organic Chemistry, Building B 2.1, Room 1.13. Saarland State University, Campus D-66123, Saarbrücken, Germany
2   Laboratoire de Botanique et Ecologie Végétale, Université de Lomé, BP 1515, Lomé, Togo
4   Université de Lorraine, SRSMC, UMR 7565, 54001, Nancy, France
5   CNRS, SRSMC, UMR 7565, ICPM, 1 boulevard Arago 57078, Metz, France
,
W Atakpama
2   Laboratoire de Botanique et Ecologie Végétale, Université de Lomé, BP 1515, Lomé, Togo
,
H Pereki
2   Laboratoire de Botanique et Ecologie Végétale, Université de Lomé, BP 1515, Lomé, Togo
,
S Fontanay
4   Université de Lorraine, SRSMC, UMR 7565, 54001, Nancy, France
5   CNRS, SRSMC, UMR 7565, ICPM, 1 boulevard Arago 57078, Metz, France
6   ABC Platform®, Faculté de Pharmacie, F-54001, Nancy, France
,
F Nana
4   Université de Lorraine, SRSMC, UMR 7565, 54001, Nancy, France
5   CNRS, SRSMC, UMR 7565, ICPM, 1 boulevard Arago 57078, Metz, France
,
ECC Ejike Chukwunonso
7   Department of Medical Biochemistry, Faculty of Basic Medical Sciences, Federal University Ndufu-Alike, Ikwo, PMB 1010, Abakaliki, Ebonyi State, Nigeria
,
G Kirsch
4   Université de Lorraine, SRSMC, UMR 7565, 54001, Nancy, France
5   CNRS, SRSMC, UMR 7565, ICPM, 1 boulevard Arago 57078, Metz, France
,
E Duval Raphael
4   Université de Lorraine, SRSMC, UMR 7565, 54001, Nancy, France
5   CNRS, SRSMC, UMR 7565, ICPM, 1 boulevard Arago 57078, Metz, France
6   ABC Platform®, Faculté de Pharmacie, F-54001, Nancy, France
,
P Chaimbault
4   Université de Lorraine, SRSMC, UMR 7565, 54001, Nancy, France
5   CNRS, SRSMC, UMR 7565, ICPM, 1 boulevard Arago 57078, Metz, France
,
D Karou Simplice
3   Ecole Supérieure des Techniques Biologiques et Alimentaires (ESTBA-UL), Université de Lomé, Lomé, Togo
,
K Batawila
2   Laboratoire de Botanique et Ecologie Végétale, Université de Lomé, BP 1515, Lomé, Togo
,
K Akpagana
2   Laboratoire de Botanique et Ecologie Végétale, Université de Lomé, BP 1515, Lomé, Togo
,
C Jacob
1   Faculty of Pharmacy, Department of Bio-organic Chemistry, Building B 2.1, Room 1.13. Saarland State University, Campus D-66123, Saarbrücken, Germany
› Author Affiliations
Further Information

Publication History

Publication Date:
24 October 2017 (online)

 

The investigation of natural products used in Traditional Medicine in Africa is complicated as modern analytical and screening methods are often not available. Computer aided product identification from traditional usage records (CAPITURE) may provide an interesting alternative and has been evaluated in the context of an ethnobotanical survey on fungal diseases and their traditional treatment in Tchamba District (Togo). 53 traditional healers were interviewed and their knowledge, recorded [1]. Several indicators, the Use Value (UV), Plant Part Value (PPV), Specific Use (SU) value, Intraspecific Use Value (IUV) and Informant Consensus Factor (ICF), were applied to the data [2,3]. Those indices, in addition to a bibliographic review, were then fed into a computer-aided approach which predicted two interesting plants (out of the 43 species survey-recorded) and their specific activities: Pterocarpus erinaceus sap against ringworm, Daniellia oliveri sap against intertrigo and respectively their roots and barks against candidiasis. Subsequent laboratory studies have confirmed the predicted antimicrobial activities with MIC (128 µg/ml to 30 mg/ml) and without any notable toxicity on normal human cells (MRC-5 cells). Although such method may not be flawless, it provides first leads, and in the face of limited resources, is an attractive alternative worth considering.

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Fig. 1

[1] Tittikpina, N. K. (2012). Contribution à l'évaluation des propriétés anti-microbiennes de: Pterocarpus erinaceus Poir (Fabaceae), Daniellia oliveri (Rolfe) Hutch. et Dalz (Fabaceae) et Anchomanes difformis (Blume) Engler (Araceae), utilisées en médecine traditionnelle dans la Préfecture de Tchamba (TOGO). [Th. D. Pharm]. [Univ. Lomé]: 89

[2] Gomez-Below, A. Economic Botany 2002, 56, 231 – 241.

[3] Gazzaneo, L. R. S, Paiva de Lucena, R. F, de Albuquerque, U. P. Journal of Ethnobiology and Ethnomedicine 2005, 1, DOI: 10.1186/1746 – 4269 – 1-9.