Protective Effects of Quercetin on Necrotizing Enterocolitis in a Neonatal Rat Model

Selçuk Yazıcı; Cansu Unden Ozcan; Adnan Adil Hismiogullari; Fatma Bahar Sunay; Teoman Ozcan; Emel Ataş Berksoy; Elif Aksoz

doi:10.1055/s-0037-1608660

American Journal of Perinatology, Table of Contents

Am J Perinatol 2018; 35(05): 434-440
DOI: 10.1055/s-0037-1608660

Original Article

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Protective Effects of Quercetin on Necrotizing Enterocolitis in a Neonatal Rat Model

Authors

Selçuk Yazıcı

¹Department of Pediatrics, Faculty of Medicine, Balikesir University, Balikesir, Turkey
Cansu Unden Ozcan

²Department of Pediatric Surgery, Faculty of Medicine, Balikesir University, Balikesir, Turkey
Adnan Adil Hismiogullari

³Department of Biochemistry, Faculty of Medicine, Balikesir University, Balikesir, Turkey
Fatma Bahar Sunay

⁴Department of Histology and Embryology, Faculty of Medicine, Balikesir University, Balikesir, Turkey
Teoman Ozcan

²Department of Pediatric Surgery, Faculty of Medicine, Balikesir University, Balikesir, Turkey
Emel Ataş Berksoy

⁵Department of Pediatrics, Dr Behçet Uz Pediatric Hospital, İzmir, Turkey
Elif Aksoz

⁶Department of Pharmacology, Faculty of Medicine, Balikesir University, Balikesir, Turkey

Abstract

Introduction Necrotizing enterocolitis (NEC) is one of the major health problems of newborn period. To date, a large amount of chemicals have been tested for NEC and some showed limited beneficial effects. The research for better results still continues. This study aims to investigate the effects of quercetin (QE) on NEC treatment in rats.

Methods Newborn rats were divided into control, NEC, and NEC + QE groups. In NEC and NEC + QE groups, experimental NEC was induced. NEC + QE group animals were also given QE. Weight changes of the animals were recorded, and serum total antioxidant status (TAS), total oxidant status (TOS), malondialdehyde (MDA), and glutathione (GSH) levels were measured. Histologic evaluation of the distal ileum and the terminal deoxynucleotidyl transferase dUTP nick end labeling staining were performed.

Results A significant increase in the TAS levels was observed in NEC + QE group. Only NEC group exhibited significantly higher TOS and MDA levels and lower GSH levels. Rats in the NEC + QE group had better histopathology and less apoptosis than NEC group.

Conclusion QE is effective in enhancing antioxidant defense mechanism, limiting oxidative stress, reducing intestinal damage, and preventing NEC development.

Keywords

quercetin - necrotizing enterocolitis - newborn - rat

Full Text

References

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