Methods for Arylethylation of Amines and Heteroarenes

Dedicated to my friend Norbert Breitschaft, who died on 7^th of February, 2018.

Abstract

Compared with standard N-methylation, benzylation, and alkylation of amines and N-heterocycles, N-arylethylation is significantly more challenging. In this Review the available methods for N-arylethylation are summarized, with a special focus on efficiency, selectivity, availability of the required building blocks, and ecological aspects.

Key words

arylethylation - phenethylation - alkylation - reductive amination - hydroamination - reduction

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