Synthesis 2018; 50(20): 4089-4096
DOI: 10.1055/s-0037-1610212
paper
© Georg Thieme Verlag Stuttgart · New York

Direct Oxytosylation of 8-Amidoquinolines by Koser’s Reagent: An Efficient Strategy for 5-Substituted 8-Amidoquinolines

Zubeda Begum
a  Center for Semiochemicals, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India   Email: [email protected]
,
G. Bhavani
a  Center for Semiochemicals, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India   Email: [email protected]
,
B. Sridhar
b  Laboratory of X-ray Crystallography, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India
,
Basireddy V. Subba Reddy*
a  Center for Semiochemicals, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India   Email: [email protected]
› Author Affiliations
Further Information

Publication History

Received: 09 May 2018

Accepted after revision: 20 June 2018

Publication Date:
07 August 2018 (online)


Abstract

A metal-free remote oxytosylation of 8-amidoquinolines has been achieved using Koser’s reagent to produce 5-tosyloxy-8-amidoquinolines in good yields. This method is compatible with various functional groups present on the aromatic ring.

Supporting Information

 
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