Synlett 2019; 30(15): 1733-1737
DOI: 10.1055/s-0037-1611821
synpacts
© Georg Thieme Verlag Stuttgart · New York

Synthesis and Hybridization Properties of Covalently Mercurated and Palladated Oligonucleotides

Dattatraya Ukale
,
Sajal Maity
,
Madhuri Hande
,
The project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 721613 and from the Academy of Finland (decisions No. 286478 and 294008).
Further Information

Publication History

Received: 07 March 2019

Accepted after revision: 16 April 2019

Publication Date:
08 May 2019 (online)

Abstract

Covalent metalation of the base moieties affords a new class of modified oligonucleotides. These organometallic oligonucleotides share many properties, notably increased hybridization affinity conferred by metal-mediated base pairing, with oligonucleotides incorporating coordinative transition-metal complexes. They are, however, set apart by their ability to retain the transition-metal ion even at extreme dilution. Such stability towards dissociation would be desirable in DNA nanotechnology and necessary in therapeutic applications. Herein we describe our efforts towards preparation and characterization of covalently mercurated and palladated oligonucleotides, highlighting in particular our recent contribution on the synthesis and potential applications of oligonucleotides incorporating dimercurated artificial nucleobases.

1 Introduction

2 Synthesis of Covalently Mercurated and Palladated Oligonucleotides

3 Hybridization Properties of Covalently Mercurated and Palladated Oligonucleotides

4 Outlook

 
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