An Inhibitory Anti-factor IX Antibody Effectively Reduces Thrombus Formation in a Rat Model of Venous Thrombosis

Giora Z. Feuerstein; John R. Toomey; Richard Valocik; Paul Koster; Arun Patel; Michael N. Blackburn

doi:10.1055/s-0037-1614852

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1999; 82(05): 1443-1445
DOI: 10.1055/s-0037-1614852

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An Inhibitory Anti-factor IX Antibody Effectively Reduces Thrombus Formation in a Rat Model of Venous Thrombosis

Authors

Giora Z. Feuerstein

¹From SmithKline Beecham Pharmaceuticals, Departments of Cardiovascular Pharmacology, King of Prussia, PA, USA
John R. Toomey

¹From SmithKline Beecham Pharmaceuticals, Departments of Cardiovascular Pharmacology, King of Prussia, PA, USA
Richard Valocik

¹From SmithKline Beecham Pharmaceuticals, Departments of Cardiovascular Pharmacology, King of Prussia, PA, USA
Paul Koster

¹From SmithKline Beecham Pharmaceuticals, Departments of Cardiovascular Pharmacology, King of Prussia, PA, USA
Arun Patel

²Protein Biochemistry and Structural Biology, King of Prussia, PA, USA
Michael N. Blackburn

³Protein Biochemistry and Structural Biology, King of Prussia, PA, USA

Abstract

Summary

An inhibitory anti-factor IX/IXa antibody (BC2) has been investigated as an anti-thrombotic agent in a rat venous thrombosis model. The treatment of rats post-injury with a single bolus dose of BC2 (3mg/kg, iv.) resulted in an ~4 fold reduction in venous thrombus mass (P = 0.043). This efficacy was matched by a minimal (<2.5 fold) prolongation of the aPTT and had no effect on the prothrombin time (PT). Heparin by comparison, given as a bolus followed by continuous infusion, at doses comparable in efficacy at reducing thrombus formation, prolonged the aPTT >50 fold. These results demonstrate that the anti-factor IX/IXa antibody (BC2), when compared to heparin, can effectively reduce venous thrombosis with less disruptive consequences on blood clotting.

Keywords

Antibodies - anticoagulants - thrombosis - factor IX

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Referenzen

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