Prevalence of Factor VQ506 and Prothrombin 20210 A Mutations in an Apparently Healthy Icelandic Population and Patients Suffering from Venous Thrombosis

Thromb Haemost 1998; 79(03): 685-686
DOI: 10.1055/s-0037-1614967

Letters to the Editor

Schattauer GmbH

Prevalence of Factor V_Q506 and Prothrombin 20210 A Mutations in an Apparently Healthy Icelandic Population and Patients Suffering from Venous Thrombosis

Ísleifur Ólafsson

¹Department of Clinical Biochemistry, Reykjavík Hospital
Sigrídur Hjaltadóttir

¹Department of Clinical Biochemistry, Reykjavík Hospital
Torfi Páll Önundarson

²Department of Hematology, National Hospital, Reykjavik, Iceland
Ragnheidur Pórarinsdóttir

¹Department of Clinical Biochemistry, Reykjavík Hospital
Vilhelmína Haraldsdóttir

¹Department of Clinical Biochemistry, Reykjavík Hospital

References
1 Bertina RM, Koeleman BPC, Koster T, Rosendaal FR, Dirven RJ, de Ronde H, van der Velden PA, Reitsma PH. Mutation in blood coagulation factor V associated with resistance to activated protein C.. Nature 1994; 369: 64-7.
2 Zöller B, Dahlbäck B. Linkage between inherited resistance to activated protein C and factor V gene mutation in venous thrombosis.. Lancet 1994; 343: 1536-8.
3 Zöller B, Svensson PJ, He X, Dahlbäck B. Identification of the same factor V mutation in 47 out of 50 thrombosis-prone families with inherited resistance to activated protein C.. J Clin Invest 1994; 94: 2521-4.
4 Dahlbäck B. Inherited thrombophilia: resistance of activated protein C as a pathogenic factor of venous thromboembolism.. Blood 1995; 85: 607-14.
5 Poort SR, Rosendaal FR, Reitsma PH, Bertina RM. A common genetic variation in the 3’-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis.. Blood 1996; 88 (10) 3698-703.
6 Rees DR, Cox M, Clegg JB. World distribution of factor V Leiden.. Lancet 1995; 346: 1133-4.
7 Hillarp A, Zöller B, Svensson PJ, Dahlbäck B. The 20210 A allele of the prothrombin gene is a common risk factor among Swedish outpatients with verified deep venous thrombosis.. Thromb Haemost 1998; 78: 990-2.