Thromb Haemost 1998; 79(05): 1056-1057
DOI: 10.1055/s-0037-1615122
Letters to the Editor
Schattauer GmbH

Methylene Tetrahydrofolate Reductase (MTHFR) 677T→C Mutation and Unexplained Early Pregnancy Loss

Elvira Grandone
1   From the Arteriosclerosis and Thrombosis Unit and Division of Obstetrics and Gynecology, I.R.C.C.S. “Casa Sollievo della Sofferenza”, S. Giovanni R. (FG); and Institute of Internal Medicine and Geriatrics, University of Palermo, Italy
,
Maurizio Margaglione
1   From the Arteriosclerosis and Thrombosis Unit and Division of Obstetrics and Gynecology, I.R.C.C.S. “Casa Sollievo della Sofferenza”, S. Giovanni R. (FG); and Institute of Internal Medicine and Geriatrics, University of Palermo, Italy
,
Donatella Colaizzo
1   From the Arteriosclerosis and Thrombosis Unit and Division of Obstetrics and Gynecology, I.R.C.C.S. “Casa Sollievo della Sofferenza”, S. Giovanni R. (FG); and Institute of Internal Medicine and Geriatrics, University of Palermo, Italy
,
Marina d’Addedda
1   From the Arteriosclerosis and Thrombosis Unit and Division of Obstetrics and Gynecology, I.R.C.C.S. “Casa Sollievo della Sofferenza”, S. Giovanni R. (FG); and Institute of Internal Medicine and Geriatrics, University of Palermo, Italy
,
Giovanna D’Andrea
1   From the Arteriosclerosis and Thrombosis Unit and Division of Obstetrics and Gynecology, I.R.C.C.S. “Casa Sollievo della Sofferenza”, S. Giovanni R. (FG); and Institute of Internal Medicine and Geriatrics, University of Palermo, Italy
,
Giuseppe Pavone
1   From the Arteriosclerosis and Thrombosis Unit and Division of Obstetrics and Gynecology, I.R.C.C.S. “Casa Sollievo della Sofferenza”, S. Giovanni R. (FG); and Institute of Internal Medicine and Geriatrics, University of Palermo, Italy
,
Giovanni Di Minno
1   From the Arteriosclerosis and Thrombosis Unit and Division of Obstetrics and Gynecology, I.R.C.C.S. “Casa Sollievo della Sofferenza”, S. Giovanni R. (FG); and Institute of Internal Medicine and Geriatrics, University of Palermo, Italy
› Author Affiliations
Further Information

Publication History

Received 03 December 1997

Accepted after revision 20 January 1998

Publication Date:
07 December 2017 (online)

 

 
  • References

  • 1 Nelen WLDM, Steegers EAP, Eskes TKA, Blom HJ. Genetic risk factor for unexplained recurrent early pregnancy loss. Lancet 1997; 350: 861.
  • 2 Steegers-Theunissen RPM, Boers GHJ, Blom HJ, Trijbels FJM, Eskes TKAB. Hyperhomocysteinemia and recurrent spontaneous abortion or abruptio placentae. Lancet 1992; 339: 1122-3.
  • 3 Grandone E, Margaglione M, Colaizzo D. et al. Factor V Leiden is associated with repeated and recurrent fetal losses. Thromb Haemost 1997; 77: 822-4.
  • 4 De Franchis R, Mancini FP, D’Angelo A. et al. Elevated total plasma homocysteine and 677C→T mutation of the 5,10-Methylenetetrahydrofolate reductase gene in thrombotic vascular disease. Am J Hum Genet 1996; 59: 262-4.
  • 5 Guttormsen AB, Ueland PM, Nesthus I. et al. Determinants and vitamin responsiveness of intermediate hyperhomocysteinemia (≥40 μmol/liter). J Clin Invest 1996; 98: 2174-83.