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Thromb Haemost 1998; 80(06): 894-898
DOI: 10.1055/s-0037-1615384
DOI: 10.1055/s-0037-1615384
Letters to the Editor
Tissue Factor Expression and Metastatic Potential of Colorectal Cancer
Further Information
Publication History
Received
13 May 1998
Accepted after revision
17 August 1998
Publication Date:
07 December 2017 (online)
Summary
Several studies have previously demonstrated tissue factor (TF) expression in solid tumors. In our study, we evaluated by immunohistochemical staining TF expression in 79 cases of colorectal cancer and 17 cases of metastatic cancer of the liver from colorectal cancer, and investigated the relationship between the clinicopathological features and TF expression.
TF was detected in the tumor of 57% of colorectal cancer patients, and its expression was significantly increased (p = 0.01) in metastatic tumors (88%). TF expression was more commonly observed in meta-static tumors than in any Dukes’ stage of primary cancer. In primary cancer, the detection of TF was more frequent in cases with lymph node metastasis (Dukes’ C, 63%) or with hematogenous metastasis (Dukes’ D, 82%) than in tumors without lymph node or hematogenous metastasis (Dukes’ A and B, 46%, p = 0.03).
These results suggest that the expression of TF is related with the metastatic potential of colorectal cancer.
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References
- 1 Nemerson Y. Tissue factor and hemostasis.. Blood 1988; 71: 1-8.
- 2 Edgington TS, Mackman N, Brand K, Ruf S. Structural biology of expression and function of tissue factor.. Thromb Haemost 1991; 66: 67-79.
- 3 Drake TA, Morrissey JH, Edgington TS. Selective cellular expression of tissue factor in human tissues. Implications for disorders of hemostasis and thrombosis.. Am J Pathol 1989; 134: 1087-97.
- 4 Fleck RA, Rao LV, Rapaport SI, Varki N. Localization of human tissue factor antigen by immunostaining with monospecific polyclonal anti-human tissue factor antibody.. Thromb Res 1990; 59: 421-37.
- 5 Gralnick HR, Abrell E. Studies of the procoagulant and fibrinolytic activity of promyelocytes in acute promyelocytic leukemia.. Br J Haematol 1973; 24: 89-99.
- 6 Wada H, Nagano T, Tomeoku M, Kuto M, Karitani Y, Deguchi K, Shirakawa S. Coagulant and fibrinolytic activities in the leukemic cells lysates.. Thromb Res 1983; 30: 315-22.
- 7 Callander NS, Varki N, Rao LV. Immunohistochemical identification of tissue factor in solid tumors.. Cancer 1992; 70: 1194-201.
- 8 Kakkar AK, Lemoine NR, Scully MF, Tebbutt S, Williamson RC. Tissue factor expression correlates with histological grade in human pancreatic cancer.. Br J Surg 1995; 82: 1101-4.
- 9 Hamada K, Kuratsu J, Saitoh Y, Nishi T, Ushio Y. Expression of tissue factor correlates with of grade of malignancy in human glioma.. Cancer 1996; 77: 1877-83.
- 10 Sturm U, Luther T, Albrecht S, Flossel C, Grossmann H, Muller M. Immunohistological detection of tissue factor in normal and abnormal human mammary glands using monoclonal antibodies. Virchows Archv.. A Pathological Anatomy and Histopathology 1992; 421: 79-86.
- 11 Higure A, Okamoto K, Hirata K, Todoroki H, Nagafuchi Y, Takeda S, Katoh H, Itoh H, Ohsato K, Nakamura S. Macrophages and neutrophils infiltrating into the liver are responsible for tissue factor expression in a rabbit model of acute obstructive cholangitis.. Thromb Haemost 1996; 75: 791-5.
- 12 Mueller BM, Reisfeld RA, Edgington TS, Ruf W. Expression of tissue factor by melanoma cells promotes efficient hematogenous metastasis.. Proc Natl Acad Sci USA 1992; 89: 11832-6.
- 13 Bromberg ME, Konigsberg WH, Madisons JF, Pawashe A, Garen A. Tissue factor promotes melanoma metastasis by a pathway independent of blood coagulation.. Proc Natl Acad Sci USA 1995; 92: 8205-9.
- 14 Fischer EG, Ruf W, Mueller BM. Tissue factor-initiated thrombin generation activates the signaling thrombin receptor on malignant melanoma cells.. Cancer Res 1995; 55: 1629-32.
- 15 Zhang Y, Deng Y, Luther T, Muller M, Ziegler R, Waldherr R, Stern DM, Nawroth PP. Tissue factor controls the balance of angiogenic and angiogenic propaties of tumor cells in mice.. J Clin Invest 1994; 94: 1320-7.
- 16 Nakamura S, Goto A, Takemoto S, Mizuguchi J, Funatsu A. Monoclonal antibodies to human tissue factor.. Thromb Haemost 1991; 65: 1216 (Abstract).
- 17 Imamura T, Iyama K, Takeya M, Kambara T, Nakamura S. Role of macrophage tissue factor in the development of the delayed hypersensitivity reaction in monkey skin.. Cell Immunol 1993; 152: 614-22.
- 18 Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thicyanate-phenol-chloroform extraction.. Anal Biochem 1987; 162: 156-9.
- 19 Scarpati EM, Wen D, Broze Jr. GJ, Miletich JP, Fladermeyer RR, Siegel NR, Sadler JE. Human tissue factor : cDNA sequence and chromosome localization of the gene.. Biochemistry 1987; 26: 5234-8.
- 20 Matsumoto K, Yamamoto J, Miura T. Lack of prognostic value of immuno-reactivity for p62 oncoprotein in colorectal carcinoma.. Int J Colorect Dis 1993; 8: 103-5.
- 21 Suzuki H, Matsumoto K, Koide A, Tada T, Fujino I, Okuda A, Shigemori C. Correlation of p53 with the clinicopathologic features and prognosis of colorectal adenocarcinoma.. Surgery Today 1994; 24: 85-7.
- 22 Mohri Y. Prognostic significance of E-Cadherin expression in human colorectal cancer tissue.. Surgery Today 1997; 27: 606-12.
- 23 Grimstad IA, Prydz H. Thromboplastin release, but not content, correlates with spontaneous metastasis of cancer cell.. Int J Cancer 1988; 41: 427-31.
- 24 Masuda M, Nakamura S, Murakami T, Koniyama Y, Takahashi H. Association of tissue factor with a gamma chain homodimer of the Ig E receptor type I in cultured human monocytes.. Eur J Immunol 1996; 26: 2529-32.
- 25 Folkman J. Tumor angiogenesis: therapeutic implications.. N Engl J Med 1971; 285: 1182-6.
- 26 Takahashi H, Satoh N, Wada K, Takakuwa E, Seki Y, Shibata A. Tissue factor in plasma of patients with disseminated intravascular coagulation.. Am J Haematol 1994; 46: 333-7.
- 27 Wada H, Nakase T, Nakaya R, Minamikawa K, Wakita Y, Kaneko T, Ohiwa M, Deguchi K, and Shirakawa S. Elevated plasma tissue factor antigen level in patients with disseminated intravascular coagulation.. Am J Haematol 1994; 45: 232-6.
- 28 Szczepanski M, Bardadine K, Zawadzki J, Pypno W. Procoagulant activity of gastric, colorectal, and renal cancer is factor VII-dependent. J Cancer Res.. Clin Oncol 1998; 114: 519-22.
- 29 Naito S, Inoue S, Kinjo M, Tanaka K. Thromboplastic and fibrinolytic activities of culture human gastric cancer cell lines.. Gann 1983; 74: 241-7.
- 30 Hu T, Bach RR, Horton R, Konigsberg WH, Todd MB. Procoagulant activity in cancer cells is dependent on tissue factor expression.. Oncol Res 1994; 6: 321-7.
- 31 Asakura H, Kamikubo Y, Goto A, Shiratori Y, Yamazaki M, Jokaji H, Saito M, Uotani C, Kumabashiri I, Morishita E. et al. Role of tissue factor in disseminated intravascular coagulation.. Thromb Res 1995; 80: 217-24.
- 32 Silberberg JM, Gordon S, Zucker S. Identification of tissue factor in two human pancreatic cancer cell lines.. Cancer Res 1989; 49: 5443-7.
- 33 Rao LV. Tissue factor as a tumor procoagulant.. Cancer Metastasis Rev 1992; 11: 249-66.
- 34 Lorenzet R, Peri G, Locati D, Allavena P, Colucci M, Semeraro N, Mantovani A, and Donati MB. Generation of procoagulant activity by mononuclear phagocytes: a possible mechanism contributing to blood clotting activation within malignant tissues.. Blood 1983; 62: 271-3.
- 35 Geczy CL, Jones A. Procoagulant induction by human lymphokine and interferon gamma/PMA on a myelomonocytic cell line, RC2a.. Br J Haematol 1988; 70: 211-8.
- 36 Gregory SA, Kornbluth RS, Helin H, Remold HG, Edgington TS. Monocyte procoagulant inducing factor: a lymphokine involved in the T cell-instructed monocytes procoagulant response to antigen.. J Immunol 1986; 137: 3231-9.
- 37 Moore KL, Andreoli SP, Esmon NL, Esmon CT, Bang NU. Endotoxin enhances tissue factor and suppresses thrombomodulin expression of human vascular endothelium in vitro.. J Clin Invest 79 124-30.
- 38 Bevilacqua MP, Pober JS, Majeau GR, Cotran RS, Gimbrone Jr. MA. Inter-leukin-1 (IL-1) induces biosythesis and cell surface expression of procoagulant activity in human vascular endothelial cells.. J Exp Med 1984; 160: 618-23.
- 39 Zhang Y, Deng Y, Wendt T, Liliensiek B, Bierhaus A, Greten J, He W, Chen B, Hach-Wunderle V, Waldeherr R, Ziegler R, Mannel D, Stern DM, Nawroth PP. Intravenous somatic gene transfer with antisense tissue factor restores blood flow by reducing tumor necrosis factor-induced tissue factor expression and fibrin deposition in mouse meth-A sarcoma.. J Clin Invest 1996; 97: 2213-24.
- 40 Shoji M, Hancock WW, Abe K, Micko C, Casper KA, Baine RM, Wilcox JN, Danave I, Dillehay DL, Matthews E, Contrino J, Morrisey JH, Gordon S, Edgington TS, Kudryk B, Kreutzer DL, Rickles FR. Activation of coagulation and angiogenesis in cancer. Immunohistochemical localization in situ of clotting proteins and vascular endothelial growth factor in human cancer.. Amer J Pathol 1998; 152: 399-411.