Pharmacokinetics and Pharmacodynamics of Lanoteplase (n-PA)

Thomas K. Nordt; Martin Moser; Benedikt Kohler; Wolfgang Kübler; Christoph Bode

doi:10.1055/s-0037-1615568

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1999; 82(S 01): 121-123
DOI: 10.1055/s-0037-1615568

Commentaries

Schattauer GmbH

Pharmacokinetics and Pharmacodynamics of Lanoteplase (n-PA)

Thomas K. Nordt

¹From the Abteilung Kardiologie, , Medizinische Klinik und Poliklinik, Universität Freiburg

,

Martin Moser

²Abteilung Kardiologie, Medizinische Klinik und Poliklinik, Universität Heidelberg, Germany

,

Benedikt Kohler

¹From the Abteilung Kardiologie, , Medizinische Klinik und Poliklinik, Universität Freiburg

,

Wolfgang Kübler

²Abteilung Kardiologie, Medizinische Klinik und Poliklinik, Universität Heidelberg, Germany

,

Christoph Bode

¹From the Abteilung Kardiologie, , Medizinische Klinik und Poliklinik, Universität Freiburg

› Institutsangaben

Abstract

Summary

In acute myocardial infarction rapid, complete, and sustained reperfusion of the infarct-related coronary artery is the most important therapeutic principle. Lanoteplase or n-PA, a third-generation plasminogen activator consisting of a deletion and point mutant of tissue-type plasminogen activator (t-PA), is a promising agent to appraoch this therapeutic goal. The molecule exhibits an increased plasma half-life allowing single-bolus administration. In this article, after characterizing the n-PA molecule, the currently available pharmacokinetic and pharmacodynamic data including the results of the InTIME study are reviewed.

Key words

Myocardial infarction - reperfusion - thrombolysis - plasminogen - activator

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Referenzen

References
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