Tissue Factor – A Receptor Involved in the Control of Cellular Properties, Including Angiogenesis

Jiang Chen; Angelika Bierhaus; Stephan Schiekofer; Martin Andrassy; Baosheng Chen; David M. Stern; Peter P. Nawroth

doi:10.1055/s-0037-1616231

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 2001; 86(01): 334-345
DOI: 10.1055/s-0037-1616231

Research Article

Schattauer GmbH

Tissue Factor – A Receptor Involved in the Control of Cellular Properties, Including Angiogenesis

Jiang Chen

¹Section Vascular Medicine, Department of Medicine IV, University Tübingen, Germany

,

Angelika Bierhaus

¹Section Vascular Medicine, Department of Medicine IV, University Tübingen, Germany

,

Stephan Schiekofer

¹Section Vascular Medicine, Department of Medicine IV, University Tübingen, Germany

,

Martin Andrassy

¹Section Vascular Medicine, Department of Medicine IV, University Tübingen, Germany

,

Baosheng Chen

³Chinese Academy of Medical Sciences, Department of Biochemistry, Peking Union Medical College, Beijing, China

,

David M. Stern

²Columbia University, Department of Physiology, New York, USA

,

Peter P. Nawroth

¹Section Vascular Medicine, Department of Medicine IV, University Tübingen, Germany

› Institutsangaben

Abstract

Summary

Tissue factor (TF), the major initiator of blood coagulation, serves as a regulator of angiogenesis, tumor growth and metastasis. In several models, TF expression mediates upregulation of the proangiogenic vasular endothelial growth factor (VEGF) that can directly act on endothelial cells to promote vessel formation. This occurs through ligand binding, activation of signaling cascades, signal transduction and alteration of growth factor expression and is mediated by both, coagulation-dependent and -independent pathways. Depending on the cell type and the biological settings, TF seems to affect cellular properties through (i) factor VIIa (FVIIa)-dependent proteolysis of factor Xa (FXa) and thrombin and subsequent activation of proteinase activated receptor (PAR) -1 and PAR-2, (ii) through direct FVIIa signaling and mitogen activated protein (MAP) kinase activation, that is conferred by a not yet identified receptor, (iii) through interaction of FVII(a) proteolytic activity and signaling of the cytoplasmic domain and (iv) through cytoplasmic signaling independent of ligand binding. The role of phosphorylation of the cytoplasmic domain and the pathways controlling phosphorylation of TF remain poorly understood.

Key words

Angiogenesis - vasculogenesis - VEGF - metastasis - tumor growth

Volltext

Referenzen

References
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