Cerebral sinovenous thrombosis during asparaginase treatment

Summary

A boy (age: 7¹/₁₂ years) with acute lymphoblastic leukaemia developed thrombosis of the sinus sagitalis superior with secondary haemorrhagic infarction while on induction treatment with vincristine, prednisone, and asparaginase. Based on this report, the potential pathogenic mechanisms are discussed with respect to congenital prothrombotic defects as well as to the role of antileukaemic treatment. Current hypotheses on mechanisms for thromboembolism in children and proposed prophylactic strategies are briefly summarized.

Zusammenfassung

Ein 7¹/₁₂ Jahre alter Knabe mit akuter lymphatischer Leukämie entwickelte während der Induktionstherapie mit Vincristin, Asparaginase und Prednison eine Thrombose des Sinus sagitalis superior mit sekundärer hämorrhagischer Infarzierung. Anhand dieses Fallbeispiels werden allfällige auslösende Faktoren (z.B. kongenitale prothrombotische Defekte) und die ursächliche Rolle der antileukämischen Therapie besprochen. Die gängigen Hypothesen für die Entstehung einer Thromboembolie beim Kind sowie mögliche präventive Strategien werden kurz zusammengefasst.

Keywords

Thrombosis - acute lymphoblastic leukaemia - asparaginase - child

Schlüsselwörter

Thrombose - akute lymphatische Leukämie - Asparaginase - Kind

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