PDF herunterladen
Tierarztl Prax Ausg K Kleintiere Heimtiere 2014; 42(03): 194-201
DOI: 10.1055/s-0038-1623763
Für Studium und Praxis
Schattauer GmbH

Behandlung von Hunden und Katzen mit systemischer Hypertension aufgrund von Nierenerkrankungen[*]

Treatment of systemic hypertension associated with kidney disease in the dog and cat
S. Buoncompagni
1   Oklahoma State University, USA
,
M. H. Bowles
1   Oklahoma State University, USA
› Institutsangaben
Weitere Informationen

Publikationsverlauf

Eingegangen: 10. Januar 2014

Akzeptiert: 17. Januar 2014

Publikationsdatum:
06. Januar 2018 (online)

    Lizenzen und Reprints

Zusammenfassung

Die systemische Hypertension ist eine bei Hunden und Katzen zunehmend diagnostizierte Erkrankung, die häufig im Zusammenhang mit einer chronischen Nierenerkrankung auftritt. Zu den wichtigen Zielen bei der Behandlung solcher Patienten gehört, eine Schädigung von Organen wie Nieren, Gehirn, Herz und Augen zu verhindern. Dieser Artikel fasst die Empfehlungen für eine antihypertensive Therapie bei Hunden und Katzen zusammen, die an einer Nierenerkrankung leiden oder bei denen ein Risiko dafür besteht. Erläutert werden dabei auch die Einleitung der Behandlung sowie die aktuell empfohlene Medikation.

Summary

Systemic hypertension is an increasingly diagnosed disorder in dogs and cats and frequently occurs secondary to chronic kidney disease. Prevention of damage to organs such as the kidneys, brain, heart, and eyes is one of the primary concerns in the management of veterinary patients with hypertension. This article reviews the guidelines for antihypertensive therapy in patients with, or at risk for, kidney disease, including the initiation of treatment and currently recommended medications.

Schlüsselwörter

Blutdruckmessung - ACE-Hemmer - Kalziumkanalblocker - Amlodipin - Proteinurie

Key words

Blood pressure measurement - angiotensin-converting enzyme inhibitor - calcium-channel blocker - amlodipine - proteinuria

* Übersetzter modifizierter Nachdruck des Artikels S. Buoncompagni, M. H. Bowles. Treatment of Systemic Hypertension Associated With Kidney Disease. Compend Contin Educ Vet 2013; 35 (5): E1–E6. Nachdruck mit freundlicher Genehmigung von The North American Veterinary Community (NAVC) and Vetstreet, Inc. © The North American Veterinary Community (NAVC) and Vetstreet, Inc. Reprinting or posting on an external website without permission from NAVC is a violation of copyright law.


 

  • Literatur

  • 1 Littman MP. Spontaneous systemic hypertension in 24 cats. J Vet Intern Med 1994; 08 (02) 79-86.
    CrossrefPubMedGoogle Scholar
  • 2 Bodey AR, Michell A. Epidemiological study of blood pressure in domestic dogs. J Small Anim Pract 1996; 37 (03) 116-125.
    CrossrefPubMedGoogle Scholar
  • 3 Maggio F, DeFrancesco TC, Atkins CE. et al. Ocular lesions associated with systemic hypertension in cats: 69 cases (1985–1998). J Am Vet Med Assoc 2000; 217 (05) 695-702.
    CrossrefPubMedGoogle Scholar
  • 4 Maher ER, McNiel EA. Pheochromocytoma in dogs and cats. Vet Clin North Am Small Anim Pract 1997; 27 (02) 359-380.
    CrossrefPubMedGoogle Scholar
  • 5 Ash RA, Harvey AM, Tasker S. Primary hyperaldosteronism in the cat: a series of 13 cases. J Feline Med Surg 2005; 07 (03) 173-182.
    CrossrefPubMedGoogle Scholar
  • 6 Struble AL, Feldman EC, Nelson RW. et al. Systemic hypertension and proteinuria in dogs with diabetes mellitus. J Am Vet Med Assoc 1998; 213 (06) 822-825.
    PubMedGoogle Scholar
  • 7 Acierno MJ, Labato MA. Hypertension in renal disease: diagnosis and treatment. Clin Tech Small Anim Pract 2005; 20 (01) 23-30.
    CrossrefPubMedGoogle Scholar
  • 8 Syme HM, Barber PJ, Markwell PJ. et al. Prevalence of systolic hypertension in cats with chronic renal failure at initial evaluation. J Am Vet Med Assoc 2002; 220 (12) 1799-1804.
    CrossrefPubMedGoogle Scholar
  • 9 Kobayashi DL, Peterson ME, Graves TK. et al. Hypertension in cats with chronic renal failure or hyperthyroidism. J Vet Intern Med 1990; 04 (02) 58-62.
    CrossrefPubMedGoogle Scholar
  • 10 Jacob F, Polzin DJ, Osborne CA. et al. Association between initial systolic blood pressure and risk of developing a uremic crisis or of dying in dogs with chronic renal failure. J Am Vet Med Assoc 2003; 222 (03) 322-329.
    CrossrefPubMedGoogle Scholar
  • 11 Brown S, Atkins C, Bagley R. et al. Guidelines for the identification, evaluation, and management of systemic hypertension in dogs and cats. J Vet Intern Med 2007; 21 (03) 542-558.
    CrossrefPubMedGoogle Scholar
  • 12 Jepson RE. Feline systemic hypertension: classification and pathogenesis. J Feline Med Surg 2011; 13 (01) 25-34.
    CrossrefPubMedGoogle Scholar
  • 13 Krapf R, Hulter HN. Arterial hypertension induced by erythropoietin and erythropoiesis-stimulating agents (ESA). Clin J Am Soc Nephrol 2009; 04 (02) 470-480.
    CrossrefPubMedGoogle Scholar
  • 14 Buranakarl C, Mathur S, Brown SA. Effects of dietary sodium chloride intake on renal function and blood pressure in cats with normal and reduced renal function. Am J Vet Res 2004; 65 (05) 620-627.
    CrossrefPubMedGoogle Scholar
  • 15 Finco DR. Association of systemic hypertension with renal injury in dogs with induced renal failure. J Vet Intern Med 2004; 18 (03) 289-294.
    CrossrefPubMedGoogle Scholar
  • 16 Bacic A, Kogika MM, Barbaro KC. et al. Evaluation of albuminuria and its relationship with blood pressure in dogs with chronic kidney disease. Vet Clin Pathol 2010; 39 (02) 203-209.
    CrossrefPubMedGoogle Scholar
  • 17 Tenhündfeld J, Wefstaedt P, Nolte IJ. A randomized controlled clinical trial of the use of benazepril and heparin for the treatment of chronic kidney disease in dogs. J Am Vet Med Assoc 2009; 234 (08) 1031-1037.
    CrossrefPubMedGoogle Scholar
  • 18 Brown SA, Finco DR, Brown CA. et al. Evaluation of the effects of inhibition of angiotensin converting enzyme with enalapril in dogs with induced chronic renal insufficiency. Am J Vet Res 2003; 64 (03) 321-327.
    CrossrefPubMedGoogle Scholar
  • 19 Atkins CE, Rausch WP, Gardner SY. et al. The effect of amlodipine and the combination of amlodipine and enalapril on the renin-angiotensin-aldosterone system in the dog. J Vet Pharmacol Ther 2007; 30 (05) 394-400.
    CrossrefPubMedGoogle Scholar
  • 20 Thomason JD, Fallaw TL, Carmichael KP. et al. Gingival hyperplasia associated with the administration of amlodipine to dogs with degenerative valvular disease (2004–2008). J Vet Intern Med 2009; 23 (01) 39-42.
    CrossrefPubMedGoogle Scholar
  • 21 Snyder PS. Amlodipine: a randomized, blinded clinical trial in 9 cats with systemic hypertension. J Vet Intern Med 1998; 12 (03) 157-162.
    CrossrefPubMedGoogle Scholar
  • 22 Mathur S, Syme H, Brown CA. et al. Effects of the calcium channel antagonist amlodipine in cats with surgically induced hypertensive renal insufficiency. Am J Vet Res 2002; 63 (06) 833-839.
    CrossrefPubMedGoogle Scholar
  • 23 Elliott J, Barber PJ, Syme HM. et al. Feline hypertension: clinical findings and response to antihypertensive treatment in 30 cases. J Small Anim Pract 2001; 42 (03) 122-129.
    CrossrefPubMedGoogle Scholar
  • 24 Cooke KL, Snyder PS. Calcium channel blockers in veterinary medicine. J Vet Intern Med 1998; 12 (03) 123-131.
    CrossrefPubMedGoogle Scholar
  • 25 Elliott J, Fletcher M, Souttar K. et al. Effect of concomitant amlodipine and benazepril therapy in the management of feline hypertension [abstract]. J Vet Intern Med 2004; 18 (05) 788.
    PubMedGoogle Scholar
  • 26 Snyder PS, Sadek D, Jones GL. Effect of amlodipine on echocardiographic variables in cats with systemic hypertension. J Vet Intern Med 2001; 15 (01) 52-56.
    CrossrefPubMedGoogle Scholar
  • 27 Helms SR. Treatment of feline hypertension with transdermal amlodipine: a pilot study. J Am Anim Hosp Assoc 2007; 43 (03) 149-156.
    CrossrefPubMedGoogle Scholar
  • 28 Jensen J, Henik RA, Brownfield M. et al. Plasma renin activity and angiotensin I and aldosterone concentrations in cats with hypertension associated with chronic renal disease. Am J Vet Res 1997; 58 (05) 535-540.
    PubMedGoogle Scholar
  • 29 Syme H. Hypertension in small animal kidney disease. Vet Clin North Am Small Anim Pract 2011; 41 (01) 63-89.
    CrossrefPubMedGoogle Scholar
  • 30 King JN, Gunn-Moore DA, Tasker S. et al. Benazepril in renal insufficiency in cats study group. Tolerability and efficacy of benazepril in cats with chronic kidney disease. J Vet Intern Med 2006; 20 (05) 1054-1064.
    CrossrefPubMedGoogle Scholar
  • 31 Mizutani H, Koyama H, Watanabe T. et al. Evaluation of the clinical efficacy of benazepril in the treatment of chronic renal insufficiency in cats. J Vet Intern Med 2006; 20 (05) 1074-1079.
    CrossrefPubMedGoogle Scholar
  • 32 Keele SJ, Smith KC, Elliott J. et al. Adrenocortical morphology in cats with chronic kidney disease (CKD) and systemic hypertension. J Vet Intern Med 2009; 23 (06) 1319-1350.
    CrossrefPubMedGoogle Scholar
  • 33 Kyles AE, Gregory CR, Wooldridge JD. et al. Management of hypertension controls postoperative neurologic disorders after renal transplantation in cats. Vet Surg 1999; 28 (06) 436-441.
    CrossrefPubMedGoogle Scholar
  • 34 Stafylas PC, Sarafidis PA. Carvedilol in hypertension treatment. Vasc Health Risk Manag 2008; 04 (01) 23-30.
    CrossrefPubMedGoogle Scholar
  • 35 Tomaschitz A, Pilz S, Ritz E. et al. Aldosterone and arterial hypertension. Nature Rev Endocrinol 2009; 06 (02) 83-93.
    PubMedGoogle Scholar
  • 36 Syme H, Markwell P. Aldosterone and plasma renin activity in cats with hypertension and/or chronic renal failure [abstract]. J Vet Intern Med 2002; 16 (03) 354.
    PubMedGoogle Scholar