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Journal of Pediatric Neurology 2019; 17(02): 057-064
DOI: 10.1055/s-0038-1624575
Original Article
Georg Thieme Verlag KG Stuttgart · New York

Outcomes of Preterm Infants with a Periventricular Venous Infarction in the Neonatal Period

Rudaina Banihani
1   Department of Newborn and Developmental Pediatrics, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
,
Paige T. Church
1   Department of Newborn and Developmental Pediatrics, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
,
Maureen Luther
2   Neonatal Follow-Up Clinic, Women & Babies Program, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
,
Alex Kiss
3   Sunnybrook Research Institute, University of Toronto, Toronto, Ontario, Canada
,
Elizabeth V. Asztalos
1   Department of Newborn and Developmental Pediatrics, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
› Author Affiliations Funding None.
Further Information

Publication History

09 November 2017

17 December 2017

Publication Date:
28 January 2018 (online)

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Abstract

We compared the neurodevelopmental outcomes of infants with and without a periventricular venous hemorrhagic infarction (PVHI). The study was designed as a case–control study. The primary outcome measure was any score of < 85 in at least one of the cognition, language, or motor domains of the Bayley Scales of Infant and Toddler Development-3rd edition (Bayley-III) at 18 to 24 months corrected age. Of 41 infants identified, 20 index infants were matched with 40 controls for analyses. No differences in the primary outcome were noted between the two groups of infants, 52.9% with PVHI compared with 62.5% without PVHI (OR: 0.68, 95% CI: 0.21–2.13; p = 0.56). Infants with a PVHI were likely to have cerebral palsy, 85% compared with 7.5%, with the majority (70%) being ambulatory. Infants with a PVHI were developmentally similar to their preterm counterparts as it related to cognition and language.

Keywords

periventricular venous infarct - neurodevelopment outcomes - preterm infants

Authors' Contributions

All authors participated in the concept and design; analysis and interpretation of data; and drafting or revising and have approved this manuscript as submitted.


 

  • References

  • 1 Asztalos EV, Church PT, Riley P, Fajardo C, Shah PS. ; Canadian Neonatal Network and Canadian Neonatal Follow-up Network Investigators. Neonatal factors associated with a good neurodevelopmental outcome in very preterm infants. Am J Perinatol 2017; 34 (04) 388-396
    Article in Thieme ConnectPubMedGoogle Scholar
  • 2 Schmidt B, Asztalos EV, Roberts RS, Robertson CM, Sauve RS, Whitfield MF. ; Trial of Indomethacin Prophylaxis in Preterms (TIPP) Investigators. Impact of bronchopulmonary dysplasia, brain injury, and severe retinopathy on the outcome of extremely low-birth-weight infants at 18 months: results from the trial of indomethacin prophylaxis in preterms. JAMA 2003; 289 (09) 1124-1129
    CrossrefPubMedGoogle Scholar
  • 3 Johnson S, Marlow N. Early and long-term outcome of infants born extremely preterm. Arch Dis Child 2017; 102 (01) 97-102
    Google Scholar
  • 4 Jarjour IT. Neurodevelopmental outcome after extreme prematurity: a review of the literature. Pediatr Neurol 2015; 52 (02) 143-152
    Google Scholar
  • 5 Paneth N. Classifying brain damage in preterm infants. J Pediatr 1999; 134 (05) 527-529
    CrossrefPubMedGoogle Scholar
  • 6 Leviton A, Kuban K, Paneth N. Intraventricular haemorrhage grading scheme: time to abandon?. Acta Paediatr 2007; 96 (09) 1254-1256
    CrossrefPubMedGoogle Scholar
  • 7 Bassan H, Feldman HA, Limperopoulos C. , et al. Periventricular hemorrhagic infarction: risk factors and neonatal outcome. Pediatr Neurol 2006; 35 (02) 85-92
    PubMedGoogle Scholar
  • 8 Ballabh P. Intraventricular hemorrhage in premature infants: mechanism of disease. Pediatr Res 2010; 67 (01) 1-8
    CrossrefPubMedGoogle Scholar
  • 9 Adler I, Batton D, Betz B. , et al. Mechanisms of injury to white matter adjacent to a large intraventricular hemorrhage in the preterm brain. J Clin Ultrasound 2010; 38 (05) 254-258
    PubMedGoogle Scholar
  • 10 Roze E, Kerstjens JM, Maathuis CG, ter Horst HJ, Bos AF. Risk factors for adverse outcome in preterm infants with periventricular hemorrhagic infarction. Pediatrics 2008; 122 (01) e46-e52
    CrossrefPubMedGoogle Scholar
  • 11 Dudink J, Lequin M, Weisglas-Kuperus N, Conneman N, van Goudoever JB, Govaert P. Venous subtypes of preterm periventricular haemorrhagic infarction. Arch Dis Child Fetal Neonatal Ed 2008; 93 (03) F201-F206
    CrossrefPubMedGoogle Scholar
  • 12 Bassan H, Limperopoulos C, Visconti K. , et al. Neurodevelopmental outcome in survivors of periventricular hemorrhagic infarction. Pediatrics 2007; 120 (04) 785-792
    CrossrefPubMedGoogle Scholar
  • 13 Roze E, Van Braeckel KN, van der Veere CN, Maathuis CG, Martijn A, Bos AF. Functional outcome at school age of preterm infants with periventricular hemorrhagic infarction. Pediatrics 2009; 123 (06) 1493-1500
    CrossrefPubMedGoogle Scholar
  • 14 Bayley N. Bayley Scales of Infant and Toddler Development. 3rd ed. San Antonio, TX: Psychological Corporation; 2005
    Google Scholar
  • 15 Askie LM, Darlow BA, Davis PG. , et al. Effects of targeting lower versus higher arterial oxygen saturations on death or disability in preterm infants. Cochrane Database Syst Rev 2017; 4: CD011190
    PubMedGoogle Scholar
  • 16 Synnes A, Luu TM, Moddemann D. , et al; Canadian Neonatal Network and the Canadian Neonatal Follow-Up Network. Determinants of developmental outcomes in a very preterm Canadian cohort. Arch Dis Child Fetal Neonatal Ed 2017; 102 (03) F235-F234
    CrossrefPubMedGoogle Scholar
  • 17 Palisano RJ, Rosenbaum P, Bartlett D, Livingston MH. Content validity of the expanded and revised Gross Motor Function Classification System. Dev Med Child Neurol 2008; 50 (10) 744-750
    CrossrefPubMedGoogle Scholar
  • 18 Schmidt B, Whyte RK, Asztalos EV. , et al; Canadian Oxygen Trial (COT) Group. Effects of targeting higher vs lower arterial oxygen saturations on death or disability in extremely preterm infants: a randomized clinical trial. JAMA 2013; 309 (20) 2111-2120
    CrossrefPubMedGoogle Scholar
  • 19 Whyte RK, Kirpalani H, Asztalos EV. , et al; PINTOS Study Group. Neurodevelopmental outcome of extremely low birth weight infants randomly assigned to restrictive or liberal hemoglobin thresholds for blood transfusion. Pediatrics 2009; 123 (01) 207-213
    CrossrefPubMedGoogle Scholar
  • 20 Schmidt B, Davis P, Moddemann D. , et al; Trial of Indomethacin Prophylaxis in Preterms Investigators. Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants. N Engl J Med 2001; 344 (26) 1966-1972
    CrossrefPubMedGoogle Scholar
  • 21 Schmidt B, Roberts RS, Davis P. , et al; Caffeine for Apnea of Prematurity Trial Group. Long-term effects of caffeine therapy for apnea of prematurity. N Engl J Med 2007; 357 (19) 1893-1902
    CrossrefPubMedGoogle Scholar
  • 22 Maitre NL, Marshall DD, Price WA. , et al. Neurodevelopmental outcome of infants with unilateral or bilateral periventricular hemorrhagic infarction. Pediatrics 2009; 124 (06) e1153-e1160
    CrossrefPubMedGoogle Scholar
  • 23 Brouwer A, Groenendaal F, van Haastert IL, Rademaker K, Hanlo P, de Vries L. Neurodevelopmental outcome of preterm infants with severe intraventricular hemorrhage and therapy for post-hemorrhagic ventricular dilatation. J Pediatr 2008; 152 (05) 648-654
    CrossrefPubMedGoogle Scholar
  • 24 Bolisetty S, Dhawan A, Abdel-Latif M, Bajuk B, Stack J, Lui K. ; New South Wales and Australian Capital Territory Neonatal Intensive Care Units' Data Collection. Intraventricular hemorrhage and neurodevelopmental outcomes in extreme preterm infants. Pediatrics 2014; 133 (01) 55-62
    CrossrefPubMedGoogle Scholar
  • 25 O'Shea TM, Allred EN, Kuban KC. , et al; ELGAN Study Investigators. Intraventricular hemorrhage and developmental outcomes at 24 months of age in extremely preterm infants. J Child Neurol 2012; 27 (01) 22-29
    CrossrefPubMedGoogle Scholar
  • 26 Radic JA, Vincer M, McNeely PD. Outcomes of intraventricular hemorrhage and posthemorrhagic hydrocephalus in a population-based cohort of very preterm infants born to residents of Nova Scotia from 1993 to 2010. J Neurosurg Pediatr 2015; 15 (06) 580-588
    CrossrefPubMedGoogle Scholar
  • 27 Dean JM, Bennet L, Back SA, McClendon E, Riddle A, Gunn AJ. What brakes the preterm brain? An arresting story. Pediatr Res 2014; 75 (1–2): 227-233
    CrossrefPubMedGoogle Scholar
  • 28 Bennet L, Van Den Heuij L, Dean JM, Drury P, Wassink G, Gunn AJ. Neural plasticity and the Kennard principle: Does it work for the preterm brain?. Clin Exp Pharmacol Physiol 2013; 40 (11) 774-784
    CrossrefPubMedGoogle Scholar
  • 29 Bassan H, Benson CB, Limperopoulos C. , et al. Ultrasonographic features and severity scoring of periventricular hemorrhagic infarction in relation to risk factors and outcome. Pediatrics 2006; 117 (06) 2111-2118
    CrossrefPubMedGoogle Scholar