Flexible Two-Stage Designs: An Overview

P. Bauer; W. Brannath; M. Posch

doi:10.1055/s-0038-1634472

Methods of Information in Medicine, Table of Contents

Methods Inf Med 2001; 40(02): 117-121
DOI: 10.1055/s-0038-1634472

Original Article

Schattauer GmbH

Flexible Two-Stage Designs: An Overview

Authors

P. Bauer

¹Department of Medical Statistics, University of Vienna
W. Brannath

¹Department of Medical Statistics, University of Vienna
M. Posch

¹Department of Medical Statistics, University of Vienna

Abstract

In this overview we introduce the basic ideas behind a new flexible approach in sequential designs. The different concepts based on two-stage combination tests and conditional error functions are brought together. We sketch the construction of p-values, confidence intervals, and median unbiased estimates. Finally, recursive combination tests are introduced which extend the flexibility to the choice of the number of interim analyses.

Keywords

Adaptive Design - Midtrial Design Modification - Two-stage Combination Test - Conditional Error Function - Confidence Interval - Recursive Combination Test

Full Text

References

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