Endoscopy 2018; 50(04): S159
DOI: 10.1055/s-0038-1637514
ESGE Days 2018 ePosters
Georg Thieme Verlag KG Stuttgart · New York

UPPER GASTROINTESTINAL BLEEDING ASSOCIATED WITH NON-STEROIDAL ANTI-INFLAMMATORY DRUGS

F Errabie
1   Mohamed VI University Hospital, Gastroenterology, Oujda, Morocco
,
A Elmekkaoui
2   Mohammed the first university/Mohammed VI University Hospital, Gastroenterology, Oujda, Morocco
,
W Khannoussi
1   Mohamed VI University Hospital, Gastroenterology, Oujda, Morocco
,
G Kharrasse
1   Mohamed VI University Hospital, Gastroenterology, Oujda, Morocco
,
Z Ismaili
1   Mohamed VI University Hospital, Gastroenterology, Oujda, Morocco
› Author Affiliations
Further Information

Publication History

Publication Date:
27 March 2018 (online)

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Aims:

The aim of our study is to evaluate the epidemiological, clinical, endoscopic and evolutionary characteristics of Upper gastrointestinal bleeding (UGIB) associated with Non-steroidal anti-inflammatory drugs (NSAIDs).

Methods:

This is a retrospective and a prospective (from March 2015 to March 2017) descriptive and analytical study, including all Adult patients admitted for UGIB following NSAID therapy.

Results:

During the study period, 78 patients were admitted (29.3%) with an average age of 56.5 years. A history of upper gastrointestinal bleeding was noted in 8.9% of cases, associated comorbidity in 34.6% cases, drug combination in 11.5% cases. NSAIDs were aspirin in 57.69% cases, non-selective NSAIDs in 42.3% cases, with a high dose in 38.4% and chronic use in 31% cases. Hemorrhage was severe in 30% cases with transfusion in 50% cases. The endoscopic lesions noted ulcerative disease in 51.28% vs. 33.5% in patients who did not take NSAIDs, p = 0.005, ulcers were bulbar in 75% cases and gastric in (25%), Were classified as Forrest III in 65% of cases, IIb in 12.5% of cases, IIa in 10% of cases and Ib in 10% of cases. Esophageal varices rupture in 14.1% vs. 28.64%, p = 0.009, oesophagitis in 12.8% vs. 14.5%, p = NS, bulbododitis in 1.28% vs. 5.9% of cases, p = NS, Vascular lesions in 2.5% vs. 2.7%, p = NS, and Malory Weiss in 1.28% vs. 0%, p = NS. Hemorrhagic recurrence was noted in 2.5% of cases and death in 2.5% of cases, with a non-statistically significant relationship between bleeding recurrence, mortality and NSAID use with p = 0.6, p = 0.5.

Conclusions:

Upper gastrointestinal bleeding associated with NSAIDs is common. In 30% cases, it is severe and life-threatening, with a mortality rate of 2.5% in our series.