Endoscopy 2018; 50(04): S200
DOI: 10.1055/s-0038-1637656
ESGE Days 2018 ePosters
Georg Thieme Verlag KG Stuttgart · New York

SERUM PHOSPHATE AS A PROGNOSTIC FACTOR IN POST-ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY PANCREATITIS

YH Choi
1   Seoul National University College of Medicine, Department of Internal Medicine and Liver Research Institute, Seoul, Korea, Republic of
,
DK Jang
2   Dongguk University Ilsan Medical Center, Department of Internal Medicine, Goyang-si, Korea, Republic of
,
YT Kim
1   Seoul National University College of Medicine, Department of Internal Medicine and Liver Research Institute, Seoul, Korea, Republic of
,
JK Ryu
1   Seoul National University College of Medicine, Department of Internal Medicine and Liver Research Institute, Seoul, Korea, Republic of
,
WH Paik
1   Seoul National University College of Medicine, Department of Internal Medicine and Liver Research Institute, Seoul, Korea, Republic of
,
J Kang
1   Seoul National University College of Medicine, Department of Internal Medicine and Liver Research Institute, Seoul, Korea, Republic of
,
JH Choi
1   Seoul National University College of Medicine, Department of Internal Medicine and Liver Research Institute, Seoul, Korea, Republic of
,
SH Lee
1   Seoul National University College of Medicine, Department of Internal Medicine and Liver Research Institute, Seoul, Korea, Republic of
› Author Affiliations
Further Information

Publication History

Publication Date:
27 March 2018 (online)

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Aims:

There is no definite prognostic marker of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP). Previous animal study reported that serum phosphate correlated with severity of acute pancreatitis. In this study, we aimed to evaluate the efficacy of serum phosphate as a prognostic factor for PEP in human.

Methods:

Between January 2005 and December 2016, 191 patients who underwent serum phosphate test among patients with PEP were included in the study. Serum phosphate was measured between 12 and 24 hours after ERCP. We assess the association between serum phosphate level and severe PEP and obtained optimal cutoff value for phosphate for severe PEP prediction.

Results:

A total of 191 patients with severe (n = 42) or mild and moderate (n = 149) PEP were included. Several factors for predicting severe PEP were identified in a multivariate analysis: malignancy as the primary diagnosis for ERCP [odds ratio (OR) 2.65, p = 0.038], systemic inflammatory response syndrome (SIRS) [OR 4.49, p = 0.016], phosphate [OR 1.97, p = 0.040]. There was a positive correlation between the phosphate and severe PEP (rs= 0.217, p < 0.003). In the receiver operating characteristic analysis, the area under the curve for phosphate for severe PEP was 0.65 (95% confidence interval: 0.56 – 0.75). The optimal cutoff value for phosphate for prediction of severe PEP was 3.35 mg/dL (sensitivity 0.62; specificity 0.73).

Conclusions:

According to our retrospective data, serum phosphate is associated with the severity of PEP, and its role as a prognostic factor for PEP can be considered.