Role of Lactoferrin in Neonates and Infants: An Update

Paolo Manzoni; Alberto Dall'Agnola; Daniel Tomé; David A. Kaufman; Elena Tavella; Marta Pieretto; Alessandro Messina; Daniele De Luca; Marc Bellaiche; Alexis Mosca; Hugues Piloquet; Umberto Simeoni; Jean-Charles Picaud; Antonio Del Vecchio

doi:10.1055/s-0038-1639359

American Journal of Perinatology, Inhaltsverzeichnis

Am J Perinatol 2018; 35(06): 561-565
DOI: 10.1055/s-0038-1639359

Review Article

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Role of Lactoferrin in Neonates and Infants: An Update

Authors

Paolo Manzoni

¹Neonatology and NICU, S. Anna Hospital, AOU Città della Salute e della Scienza, Torino, Italy
Alberto Dall'Agnola

²Department of Neonatology, Ospedale P. Pederzoli, Verona, Italy
Daniel Tomé

³UMR PNCA, AgroParisTech, Institut National de la Recherche Agronomique, Université Paris-Saclay, Paris, France
David A. Kaufman

⁴Division of Neonatology, Department of Pediatrics, University of Virginia School of Medicine and Children's Hospital, Charlottesville, Virginia
Elena Tavella

¹Neonatology and NICU, S. Anna Hospital, AOU Città della Salute e della Scienza, Torino, Italy
Marta Pieretto

¹Neonatology and NICU, S. Anna Hospital, AOU Città della Salute e della Scienza, Torino, Italy
Alessandro Messina

¹Neonatology and NICU, S. Anna Hospital, AOU Città della Salute e della Scienza, Torino, Italy
Daniele De Luca

⁵Department of Pediatrics and Neonatal Critical Care, “A.Béclère” Medical Centre, South Paris University Hospitals, South Paris-Saclay University, Paris, France
Marc Bellaiche

¹Neonatology and NICU, S. Anna Hospital, AOU Città della Salute e della Scienza, Torino, Italy
Alexis Mosca

¹Neonatology and NICU, S. Anna Hospital, AOU Città della Salute e della Scienza, Torino, Italy
Hugues Piloquet

¹Neonatology and NICU, S. Anna Hospital, AOU Città della Salute e della Scienza, Torino, Italy
Umberto Simeoni

¹Neonatology and NICU, S. Anna Hospital, AOU Città della Salute e della Scienza, Torino, Italy
Jean-Charles Picaud

⁶Service de Réanimation Néonatale, Université, Hôpital de la Croix Rousse, Lyon, France
Antonio Del Vecchio

⁷Department of Women's and Children's Health, ASL Bari, Bari, Italy

Abstract

Lactoferrin is one of the most represented and important bioactive proteins in human and mammal milk. In humans, lactoferrin is responsible for several actions targeting anti-infective, immunological, and gastrointestinal domains in neonates, infants, and young children. Evidence-based data vouch for the ability of supplemented lactoferrin to prevent sepsis and necrotizing enterocolitis in preterm infants and to reduce the burden of morbidity related to gastrointestinal and respiratory pathogens in young children. However, several issues remain pending regarding answers and clarification related to quality control, correct intakes, optimal schedules and schemes of supplementations, interactions with probiotics, and different types of milk and formulas. This review summarizes the current evidence regarding lactoferrin and discusses the areas in need of further guidance prior to the adoption of strategies that include a routine use of lactoferrin in neonates and young children.

Keywords

lactoferrin - neonates - infant - nutrition - infection - sepsis - necrotizing enterocolitis

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Referenzen

References
1 Lönnerdal B. Nutritional and physiologic significance of human milk proteins. Am J Clin Nutr 2003; 77 (06) 1537S-1543S
2 Hylander MA, Strobino DM, Dhanireddy R. Human milk feedings and infection among very low birth weight infants. Pediatrics 1998; 102 (03) E38
3 Ronayne de Ferrer PA, Baroni A, Sambucetti ME, López NE, Ceriani Cernadas JM. Lactoferrin levels in term and preterm milk. J Am Coll Nutr 2000; 19 (03) 370-373
4 Rai D, Adelman AS, Zhuang W, Rai GP, Boettcher J, Lönnerdal B. Longitudinal changes in lactoferrin concentrations in human milk: a global systematic review. Crit Rev Food Sci Nutr 2014; 54 (12) 1539-1547
5 Prentice A, MacCarthy A, Stirling DM, Vasquez-Velasquez L, Ceesay SM. Breast-milk IgA and lactoferrin survival in the gastrointestinal tract--a study in rural Gambian children. Acta Paediatr Scand 1989; 78 (04) 505-512
6 Siciliano R, Rega B, Marchetti M, Seganti L, Antonini G, Valenti P. Bovine lactoferrin peptidic fragments involved in inhibition of herpes simplex virus type 1 infection. Biochem Biophys Res Commun 1999; 264 (01) 19-23
7 Akiyama Y, Oshima K, Kuhara T. , et al. A lactoferrin-receptor, intelectin 1, affects uptake, sub-cellular localization and release of immunochemically detectable lactoferrin by intestinal epithelial Caco-2 cells. J Biochem 2013; 154 (05) 437-448
8 Kuwata H, Yip TT, Tomita M, Hutchens TW. Direct evidence of the generation in human stomach of an antimicrobial peptide domain (lactoferricin) from ingested lactoferrin. Biochim Biophys Acta 1998; 1429 (01) 129-141
9 Valenti P, Antonini G. Lactoferrin: an important host defence against microbial and viral attack. Cell Mol Life Sci 2005; 62 (22) 2576-2587
10 Chanda W, Joseph TP, Wang W, Padhiar AA, Zhong M. The potential management of oral candidiasis using anti-biofilm therapies. Med Hypotheses 2017; 106: 15-18
11 Mastromarino P, Capobianco D, Campagna G. , et al. Correlation between lactoferrin and beneficial microbiota in breast milk and infant's feces. Biometals 2014; 27 (05) 1077-1086
12 Legrand D, Mazurier J. A critical review of the roles of host lactoferrin in immunity. Biometals 2010; 23 (03) 365-376
13 Ward PP, Uribe-Luna S, Conneely OM. Lactoferrin and host defense. Biochem Cell Biol 2002; 80 (01) 95-102
14 Buccigrossi V, de Marco G, Bruzzese E. , et al. Lactoferrin induces concentration-dependent functional modulation of intestinal proliferation and differentiation. Pediatr Res 2007; 61 (04) 410-414
15 Pammi M, Abrams SA. Oral lactoferrin for the prevention of sepsis and necrotizing enterocolitis in preterm infants. Cochrane Database Syst Rev 2015; (02) CD007137
16 Pammi M, Suresh G. Enteral lactoferrin supplementation for prevention of sepsis and necrotizing enterocolitis in preterm infants. Cochrane Database Syst Rev 2017; 6: CD007137
17 Decembrino L, DeAmici M, De Silvestri A, Manzoni P, Paolillo P, Stronati M. Plasma Lactoferrin levels in newborn preterm infants with sepsis. J Matern Fetal Neonatal Med 2017; 30 (23) 2890-2893
18 Ando K, Hasegawa K, Shindo K. , et al. Human lactoferrin activates NF-kappaB through the Toll-like receptor 4 pathway while it interferes with the lipopolysaccharide-stimulated TLR4 signaling. FEBS J 2010; 277 (09) 2051-2066
19 Ochoa TJ, Chea-Woo E, Baiocchi N. , et al. Randomized double-blind controlled trial of bovine lactoferrin for prevention of diarrhea in children. J Pediatr 2013; 162 (02) 349-356
20 Zavaleta N, Figueroa D, Rivera J, Sánchez J, Alfaro S, Lönnerdal B. Efficacy of rice-based oral rehydration solution containing recombinant human lactoferrin and lysozyme in Peruvian children with acute diarrhea. J Pediatr Gastroenterol Nutr 2007; 44 (02) 258-264
21 Håversen LA, Engberg I, Baltzer L, Dolphin G, Hanson LA, Mattsby-Baltzer I. Human lactoferrin and peptides derived from a surface-exposed helical region reduce experimental Escherichia coli urinary tract infection in mice. Infect Immun 2000; 68 (10) 5816-5823
22 Manzoni P, Memo L, Mostert M. , et al. Use of erythropoietin is associated with threshold retinopathy of prematurity (ROP) in preterm ELBW neonates: a retrospective, cohort study from two large tertiary NICUs in Italy. Early Hum Dev 2014; 90 (Suppl. 02) S29-S33
23 Tamano S, Sekine K, Takase M, Yamauchi K, Iigo M, Tsuda H. Lack of chronic oral toxicity of chemopreventive bovine lactoferrin in F344/DuCrj rats. Asian Pac J Cancer Prev 2008; 9 (02) 313-316
24 Manzoni P. Clinical benefits of lactoferrin for infants and children. J Pediatr 2016; 173 (Suppl): S43-S52
25 Franco I, Pérez MD, Conesa C, Calvo M, Sánchez L. Effect of technological treatments on bovine lactoferrin: An overview. Food Res Int 2018; 106: 173-182
26 Rollo DE, Radmacher PG, Turcu RM, Myers SR, Adamkin DH. Stability of lactoferrin in stored human milk. J Perinatol 2014; 34 (04) 284-286
27 Raoof NA, Adamkin DH, Radmacher PG, Telang S. Comparison of lactoferrin activity in fresh and stored human milk. J Perinatol 2016; 36 (03) 207-209
28 Chantry CJ, Wiedeman J, Buehring G. , et al. Effect of flash-heat treatment on antimicrobial activity of breastmilk. Breastfeed Med 2011; 6 (03) 111-116
29 Bengoechea C, Peinado I, McClements DJ. Formation of protein nanoparticles by controlled heat treatment of lactoferrin: factors affecting particle characteristics. Food Hydrocoll 2011; 25: 1354-1360
30 Moreno-Expósito L, Illescas-Montes R, Melguizo-Rodríguez L, Ruiz C, Ramos-Torrecillas J, de Luna-Bertos E. Multifunctional capacity and therapeutic potential of lactoferrin. Life Sci 2018; 195: 61-64
31 Puddu P, Valenti P, Gessani S. Immunomodulatory effects of lactoferrin on antigen presenting cells. Biochimie 2009; 91 (01) 11-18
32 Blais A, Fan C, Voisin T. , et al. Effects of lactoferrin on intestinal epithelial cell growth and differentiation: an in vivo and in vitro study. Biometals 2014; 27 (05) 857-874