Decreased Circulating Insulin-Like Growth Factor 1 Levels Are Associated with Cardiac Diastolic Dysfunction in Small for Gestational Age Infants

Yohei Akazawa; Shoko Yamazaki; Haruka Obinata; Akira Hachiya; Motoko Kamiya; Noriko Motoki; Tomohiko Nakamura

doi:10.1055/s-0038-1642060

American Journal of Perinatology, Table of Contents

Am J Perinatol 2018; 35(12): 1178-1185
DOI: 10.1055/s-0038-1642060

Original Article

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Decreased Circulating Insulin-Like Growth Factor 1 Levels Are Associated with Cardiac Diastolic Dysfunction in Small for Gestational Age Infants

Authors

Yohei Akazawa

¹Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Nagano, Japan
Shoko Yamazaki

¹Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Nagano, Japan
Haruka Obinata

¹Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Nagano, Japan
Akira Hachiya

¹Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Nagano, Japan
Motoko Kamiya

¹Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Nagano, Japan
Noriko Motoki

¹Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Nagano, Japan
Tomohiko Nakamura

²Division of Neonatology, Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Nagano, Japan

³Division of Neonatology, Nagano Children's Hospital, Azumino, Nagano, Japan

Abstract

Objective To evaluate the impact of serum insulin-like growth factor-1 (IGF-1) levels on cardiac function in small for gestational age (SGA) infants.

Study Design This is a prospective, observational study. Serum IGF-1 levels at birth and echocardiography measurements at 1 week of age were compared between SGA and appropriate for gestational age (AGA) infants.

Results Thirty-one SGA infants and 27 AGA infants were enrolled. Serum IGF-1 levels were lower in the SGA infants than in the AGA infants. SGA infants had lower mitral lateral annular systolic (S') and early diastolic (E') tissue Doppler imaging velocities compared with AGA infants (S', 5.1 ± 0.9 vs 5.7 ± 1.2 cm/s; E', 6.1 ± 1.5 cm/s vs 7.1 ± 1.3 cm/s; p < 0.05). Serum IGF-1 levels positively correlated with E' velocity in the entire population (r = 0.44, p < 0.001) and in SGA infants (r = 0.39, p < 0.05). In multivariate linear regression analysis, serum IGF-1 and S' velocity were independently associated with E' velocity in the entire population and in SGA infants.

Conclusion Decreased serum IGF-I levels could account for cardiac diastolic dysfunction in SGA infants.

Keywords

fetal programming - intrauterine growth restriction - small for gestational age infant - insulin-like growth factor-1 - cardiac dysfunction - systolic–diastolic coupling

Full Text

References

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