Kinetic Aspects of the Interaction of Blood Clotting Enzymes

H C Hemker; J Kop; G M Willems

doi:10.1055/s-0038-1646650

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1979; 41(02): 309-313
DOI: 10.1055/s-0038-1646650

Original Articles

Schattauer GmbH Stuttgart

Kinetic Aspects of the Interaction of Blood Clotting Enzymes

VIII. The Relation between Clotting Time and Clotting Velocity

Authors

H C Hemker

Department of Biochemistry, State University Limburg, Maastricht, The Netherlands
J Kop

Department of Biochemistry, State University Limburg, Maastricht, The Netherlands
G M Willems

Department of Biochemistry, State University Limburg, Maastricht, The Netherlands

Abstract

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Summary

It is shown that in a system where thrombin acts on fibrinogen, the clotting time can be used to assess coagulation velocity because clotting time and clotting velocity are inversely proportional.

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References

References
1 Hemker HC, Hemker PW. 1969; The kinetics of enzyme cascades. Proceedings of the Royal Society B 173: 411
2 Hemker HC, Siepel T, Altman R, Loeliger EA. 1967; Kinetic aspects of the interaction of blood clotting enzymes. II. The relation between clotting time and plasma concentration in prothrombin-time estimations. Thrombosis et Diathesis Haemorrhagica 17: 350
3 Hemker HC, Vermeer C, Govers-Riemslag J. 1977; Kinetic aspects of the interaction of blood clotting enzymes. VII. The relation between clotting time and prothrombin concentration Thrombosis and Haemostasis 37: 81