Recombinant Human Erythropoietin Increases Blood Pressure, Platelet Aggregability and Platelet Free Calcium Mobilisation in Uraemic Children: A Possible Link?

Chris Van Geet; Rita Van Damme-Lombaerts; Marleen Vanrusselt; An de MOl; Willy Proesmans; Jos Vermylen

doi:10.1055/s-0038-1647144

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1990; 64(01): 007-010
DOI: 10.1055/s-0038-1647144

Original Article

Schattauer GmbH Stuttgart

Recombinant Human Erythropoietin Increases Blood Pressure, Platelet Aggregability and Platelet Free Calcium Mobilisation in Uraemic Children: A Possible Link?^[*]

Authors

Chris Van Geet

¹The Centre for Thrombosis and Vascular Research, University of Leuven, Belgium

²Department of Paediatrics (Nephrology), University of Leuven, Belgium
Rita Van Damme-Lombaerts

²Department of Paediatrics (Nephrology), University of Leuven, Belgium
Marleen Vanrusselt

¹The Centre for Thrombosis and Vascular Research, University of Leuven, Belgium
An de MOl

²Department of Paediatrics (Nephrology), University of Leuven, Belgium
Willy Proesmans

²Department of Paediatrics (Nephrology), University of Leuven, Belgium
Jos Vermylen

¹The Centre for Thrombosis and Vascular Research, University of Leuven, Belgium

Abstract

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Summary

Recombinant human erythropoietin was administered to 10 uraemic children on chronic haemodialysis, all of whom responded by correcting their haemoglobin. In addition, they showed an increase in blood pressure; platelet aggregations, subnormal before therapy, improved during treatment. The intracellular free calcium concentration in platelets after thrombin stimulation also increased significantly during erythropoietin administration. We hypothesize that the effect of erythropoietin on platelet aggregability and on blood pressure may be due to an increase in the intracellular free calcium mobilisation in platelets and possibly in smooth muscle cells respectively.

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References

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Recombinant Human Erythropoietin Increases Blood Pressure, Platelet Aggregability and Platelet Free Calcium Mobilisation in Uraemic Children: A Possible Link?[*]

Authors

Recombinant Human Erythropoietin Increases Blood Pressure, Platelet Aggregability and Platelet Free Calcium Mobilisation in Uraemic Children: A Possible Link?^[*]