Protein C Deficiency in Insulin-Dependent Diabetes: A Hyperglycemia-Related Phenomenon

Antonio Ceriello; Antonio Quatraro; Patrizia Dello Russo; Egidio Marchi; Miriam Barbanti; Maria Rita Milani; Dario Giugliano

doi:10.1055/s-0038-1647262

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1990; 64(01): 104-107
DOI: 10.1055/s-0038-1647262

Original Article

Schattauer GmbH Stuttgart

Protein C Deficiency in Insulin-Dependent Diabetes: A Hyperglycemia-Related Phenomenon

Authors

Antonio Ceriello

^*The Cattedra di Diabetologia e Dietoterapiá, I Facolti di Medicina, Universita di Napoli, Napoli
Antonio Quatraro

^**The Centro di Diabetologia, Casa di Cura S. Rita, Taranto
Patrizia Dello Russo

^*The Cattedra di Diabetologia e Dietoterapiá, I Facolti di Medicina, Universita di Napoli, Napoli
Egidio Marchi

^***The Alfa Ricerche, Bologna, Italy
Miriam Barbanti

^***The Alfa Ricerche, Bologna, Italy
Maria Rita Milani

^***The Alfa Ricerche, Bologna, Italy
Dario Giugliano

^*The Cattedra di Diabetologia e Dietoterapiá, I Facolti di Medicina, Universita di Napoli, Napoli

Abstract

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Summary

In 30 insulin-dependent diabetic patients protein C (PC) antigen and PC activity were significantly lower than those of matched control healthy subjects. An inverse correlation between fasting plasma glucose and both PC concentration and activity was present in diabetics, while a direct correlation between PC concentration and PC activity was observed. Induced hyperglycemia in diabetic and normal subjects was able to decrease both PC antigen levels and PC activity, and heparin reversed in part this effect.

In diabetic patients euglycemia obtained by insulin infusion restored to normal the depressed PC levels. Heparin did not alter both the basal PC concentration and activity in healthy controls.

These data stress the major role of hyperglycemia in determining PC decrease in diabetics, and suggest that PC reduction is probably associated to hyperglycemia-enhanced thrombin formation.

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References

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