Summary
The effect of intravenous, intraaortal and intraportal injection of thrombin on the
distribution of intra vascular fibrin in various organs was determined by a quantitative
method in the rat. It was found that the major part of the fibrin was trapped in the
lungs irrespective of the route of administration of the thrombin.
These results suggest that in thrombin induced intravascular coagulation most of the
coagulation occurs on the venous side of the circulation.
This mechanism may be an explanation for the fact that certain organs more often contain
intravascular fibrin than others at autopsy.
