Summary
In order to find out which hemostasis parameters would have the predictive value for
the development of preeclampsia, modified antithrombin III (ATM, representative of
the antithrombin Ill-serine esterase complex), tissue plasminogen activator (tPA),
plasminogen activator inhibitor-1 (PAI-1), beta-throm-boglobulin (BTG), antithrombin
III (AT III), fibrinogen, fibrin(ogen) degradation product (FDP), FDP D-dimer and
euglobulin lysis time (ELT) were measured in 20 normal nonpregnant women, 21 normal
pregnant women, 6 high-risk pregnant women, 14 preeclampsia pregnant women, and 5
patients with disseminated intravascular coagulation (DIC). Only tPA and AT III were
found significantly different between the preeclampsia and the normal or high-risk
pregnant women: tPA was found progressively and significantly increased from the normal
pregnant, to the high-risk pregnant, then to the preeclampsia women (p <0.05). AT III was significantly lower in the preeclampsia than in the normal pregnant
(p = 0.0001) or in the high-risk pregnant women (p = 0.002). In the 2nd trimester, tPA, PAI, fibrinogen and FDP were significantly higher,
and AT III was significantly lower in the preeclampsia than in the normal pregnant
women, whereas in the 3rd trimester, tPA and AT III were significantly higher or lower,
respectively, in the preeclampsia than in the normal pregnant women. No significant
difference of ATM could be found between the preeclampsia and the normal or high-risk
pregnant women. From the present study, we suggest that tPA and AT III would be used
as the main predictors, and FDP and D-dimer as the complementary predictors for the
development of preeclampsia and should be detected in the normal or high-risk pregnant
women.
