Factor VII Antigen Levels in a Healthy Blood Donor Population

P R Howard; E G Bovill; J Pike; W R Chruch; R P Tracy

doi:10.1055/s-0038-1648805

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1994; 72(01): 021-027
DOI: 10.1055/s-0038-1648805

Original Article

Schattauer GmbH Stuttgart

Factor VII Antigen Levels in a Healthy Blood Donor Population

Authors

P R Howard

¹The University of Vermont Department of Medical Technology, Burlington, VT, USA
E G Bovill

²Department of Pathology, Vermont Thrombosis Center, Burlington, VT, USA
J Pike

³Department of Biochemistry, Vermont Thrombosis Center, Burlington, VT, USA
W R Chruch

³Department of Biochemistry, Vermont Thrombosis Center, Burlington, VT, USA
R P Tracy

²Department of Pathology, Vermont Thrombosis Center, Burlington, VT, USA

³Department of Biochemistry, Vermont Thrombosis Center, Burlington, VT, USA

Abstract

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Summary

We determined factor VII antigen (FVIIag) levels in 705 healthy blood donors ranging in age from 17 to 79 years using a two-site solid-phase enzyme immunoassay developed in our laboratory. The mean (± SD) FVIIag level for the total population was 102 ± 31%. FVIIag levels for men (n = 375) and women (n = 330) were 101 ± 28% and 103 ± 33%, respectively. A significant increase in FVIIag was observed with age in both men (r = 0.25, p <0.0001) and women (r = 0.35, p <0.0001). FVIIag levels were significantly higher in women > 60 years when compared to men (median women: 125%; median men: 111%; p <0.05). On a subset of the study group (n = 45), FVIIag levels were correlated to total cholesterol (r = 0.27, p = 0.08) and triglyceride (r = 0.41, p <0.01). Assuming the commonly used reference interval of 60-140% for FVII, the frequencies of FVIIag values for <60% and >140% using our assay were 2.1% and 9.2%, respectively. Gender and age-related differences in FVIIag levels must be considered in a reference interval. We further suggest that assay-specific reference ranges be established, which may include values outside the commonly used values of 60-140%.

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References

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