Circulating Endothelial Cell/Leukocyte Adhesion Molecules in Atherosclerosis

Andrew D Blann; Charles N McCollum

doi:10.1055/s-0038-1648827

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1994; 72(01): 151-154
DOI: 10.1055/s-0038-1648827

Original Article

Schattauer GmbH Stuttgart

Circulating Endothelial Cell/Leukocyte Adhesion Molecules in Atherosclerosis

Authors

Andrew D Blann

The Department of Surgery, University Hospital of South Manchester, Didsbury, Manchester, UK
Charles N McCollum

The Department of Surgery, University Hospital of South Manchester, Didsbury, Manchester, UK

Abstract

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Summary

Soluble adhesion molecules E-selectin, intercellular adhesion molecule (sICAM) and vascular cell adhesion molecule (sVCAM) were measured alongside von Willebrand factor (vWf) in 40 patients with peripheral vascular disease (PVD), 43 with ischaemic heart disease (IHD) and in equal numbers of age and sex matched asymptomatic controls. Increased vWf was found in patients with IHD (p = 0.0008) and in patients with PVD (p = 0.0001) relative to their respective controls but levels did not differ between the two patient groups. Raised sICAM was found in both PVD (p = 0.0003) and IHD (p = 0.0059) compared to their respective controls and was higher in PVD than in IHD (p = 0.0088). In the subjects taken as a whole, there was no correlation between vWf and sICAM. Levels of soluble E-sel-ectin and sVCAM did not differ in patients or controls. These data suggest that soluble ICAM may be useful as an index of endothelial cell activation in clinical manifestations of atherosclerosis.

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References

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