Tranexamic Acid in the Control of Spontaneous Bleeding in Severe Haemophilia

S. G Rainsford; A. J Jouhar; Angela Hall

doi:10.1055/s-0038-1649074

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1973; 30(02): 272-279
DOI: 10.1055/s-0038-1649074

Original Article

Schattauer GmbH

Tranexamic Acid in the Control of Spontaneous Bleeding in Severe Haemophilia

Authors

S. G Rainsford

¹Lord Mayor Treloar Hospital, Alton, Hampshire, and Kabi Pharmaceuticals Limited, Ealing, London
A. J Jouhar

¹Lord Mayor Treloar Hospital, Alton, Hampshire, and Kabi Pharmaceuticals Limited, Ealing, London
Angela Hall

¹Lord Mayor Treloar Hospital, Alton, Hampshire, and Kabi Pharmaceuticals Limited, Ealing, London

Abstract

Summary

A double-blind cross-over study of the prophylactic value of tranexamic acid (“Cyklokapron”), in a dose of 3.0 g per day, against spontaneous bleeding episodes in severe haemophilia was undertaken. Records of bleeding episodes were maintained during therapy in twenty boys with confirmed clinical severity, over two school terms. A significant reduction (p <0.05) in spontaneous bleeding episodes was attained with an associated lessening in the transfusion requirement of therapeutic material, and without obvious side effects. Recommendations are made for further investigations.

Full Text

References

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