The Effect of Some Synthetic Arginyl and Lysyl Compounds on Clotting and Fibrinolysis

M. J Weinstein; R. F Doolittle

doi:10.1055/s-0038-1649094

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1972; 28(02): 289-298
DOI: 10.1055/s-0038-1649094

Original Article

Schattauer GmbH

The Effect of Some Synthetic Arginyl and Lysyl Compounds on Clotting and Fibrinolysis

Authors

M. J Weinstein

¹Department of Chemistry, University of California, San Diego La Jolla, California, U.S.A.
R. F Doolittle

¹Department of Chemistry, University of California, San Diego La Jolla, California, U.S.A.

Abstract

Summary

The effects of a number of synthetic arginyl- and lysyl-compounds on clotting and fibrinolysis have been studied. The lysyl derivatives had no significant effect on the clotting of recalcified plasma or recalcified euglobulin preparations, but tosyllysine (TL) and tosyllysine methyl ester (TLME) were very effective inhibitors of fibrinolysis. Certain arginyl-peptides (in particular, tosylarginylsarcosine methyl ester) were very effective at delaying clotting in these systems. These same substances gave rise to an exaggerated thrombin production, however, evidently by interfering with the natural thrombin activation of plasma antithrombin(s).

Full Text

References

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