Systemic Effects of ADP-induced Platelet Aggregation and Their Modification by Aspirin and by Pyridinolcarbamate

Itsuro Kobayashi; Paul Didisheim

doi:10.1055/s-0038-1649115

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1973; 30(01): 178-190
DOI: 10.1055/s-0038-1649115

Original Article

Schattauer GmbH

Systemic Effects of ADP-induced Platelet Aggregation and Their Modification by Aspirin and by Pyridinolcarbamate

Authors

Itsuro Kobayashi^*

¹Section of Laboratory Hematology, Department of Laboratory Medicine, Mayo Clinic, Rochester, Minnesota, 55901, U.S.A.
Paul Didisheim

¹Section of Laboratory Hematology, Department of Laboratory Medicine, Mayo Clinic, Rochester, Minnesota, 55901, U.S.A.

Abstract

Summary

ADP, AMP, or ATP was injected rapidly intravenously in rats. ADP injection resulted in the f olio wing transient changes: a drop in platelet count, a rise in central venous pressure, a fall in carotid arterial PO₂, bradycardia, arrhythmia, flutter-fibrillation, and arterial hypotension. AMP and ATP produced some of these same effects; but except for hypotension, their frequency and severity Avere much less than those following ADP.

Prior intravenous administration of acetylsalicylic acid or pyridinolcarbamate, two inhibitors of the second wave of ADP-induced platelet aggregation in vitro, significantly reduced the frequency and severity of all the above ADP-induced changes except hypotension. These observations suggest that many of the changes (except hypotension) observed to follow ADP injection are produced by platelet aggregates which lodge transiently in various microcirculatory beds then rapidly disaggregate and recirculate.

Full Text

References

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