Thrombosis and Haemostasis, Table of Contents Thromb Haemost 1972; 27(02): 241-245DOI: 10.1055/s-0038-1649362 Originalarbeiten — Original Articles — Travaux Originaux Schattauer GmbH Quantitative Monitoring of Intravascular Coagulation and Fibrinolysis in the Lungs of Rats Authors Author Affiliations D Coombey 1 Research Division, Pfizer Limited, Sandwich, Kent, England H. M Tyler 1 Research Division, Pfizer Limited, Sandwich, Kent, England Recommend Article Abstract Buy Article(opens in new window) Summary A method is described whereby the arrival and subsequent lysis of thrombin- induced, 125I-labelled, pulmonary emboli can be quantitatively monitored in the rat. A scintillation probe placed over one lung monitors radioactivity in that organ ; serial counts or a continuous recording of radioactivity can be made. Radioactivity counted in serial blood samples also reflect the defibrination and fibrinolytic processes. The influence of the inhibitor EACA, and the lytic agent Brinase are described. Full Text References References 1 Laki K. The polymerization of proteins. The action of thrombin on fibrinogen. Arch. Biochem 32: 317 1951; 2 MacFarlane A. S. Efficient trace-labelling of proteins with iodine. Nature (Lond) 182: 53 1958; 3 Maxwell R. E, Nickel V. S. Fibrinogen (Plasminogen-deficient). Biochemical Preparations 12: 16 1968; 4 Regoeczi E, Brain M. C. Organ distribution of fibrin in disseminated intravascular coagulation. Brit. J. Haemat 17: 73 1969; 5 Saldeen T. Quantitative determination of intravascular coagulation in the lungs of experimental animals. Scand. J. Haemat 06: 205 1969;
