Reptilase-Induced Shortening of Coagulation Times in Normal and Hemophilic Individuals

A. J Harder; H Stadelmann; P. W Straub

doi:10.1055/s-0038-1649373

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1972; 27(02): 349-360
DOI: 10.1055/s-0038-1649373

Originalarbeiten – Original Articles – Travaux Originaux

Schattauer GmbH

Reptilase-Induced Shortening of Coagulation Times in Normal and Hemophilic Individuals^[*]

Authors

A. J Harder

¹Department of Medicine, Kantonsspital, University of Zürich, Switzerland
H Stadelmann

¹Department of Medicine, Kantonsspital, University of Zürich, Switzerland
P. W Straub

¹Department of Medicine, Kantonsspital, University of Zürich, Switzerland

Abstract

Summary

In 5 normal volunteers infusion of small doses of Reptilase-def., a thrombin-like snake venom enzyme of Bothrops atrox, led to a transient shortening of the clotting time, which was significant when compared with a control group infused with glucose. In hemophilic individuals, clotting and recalcification times were also considerably shortened, the maximal effect in both groups occurring simultaneously with cryoprecipitability and positive paracoagulation phenomena. Whether this accelerating effect on blood coagulation is mediated by circulating soluble fibrin complexes, is not yet established. However, the clot-promoting action of Reptilase must predominantly be localized at the level of fibrinogen/fibrin conversion rather than in earlier phases of coagulation.

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Referenzen

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Reptilase-Induced Shortening of Coagulation Times in Normal and Hemophilic Individuals[*]

Authors

Reptilase-Induced Shortening of Coagulation Times in Normal and Hemophilic Individuals^[*]