Increased Bleeding during Liver Resection in Ethanol-Intoxicated Rats

Stig Bengmark; Göran Göransson; Jan Idvall; Evita Zoucas

doi:10.1055/s-0038-1650052

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1980; 43(03): 203-207
DOI: 10.1055/s-0038-1650052

Original Article

Schattauer GmbH Stuttgart

Increased Bleeding during Liver Resection in Ethanol-Intoxicated Rats

Authors

Stig Bengmark

The Department of Surgery, University of Lund, Lund, Sweden and the Department of Anesthesiology, University of Lund, Malmö, Sweden
Göran Göransson

The Department of Surgery, University of Lund, Lund, Sweden and the Department of Anesthesiology, University of Lund, Malmö, Sweden
Jan Idvall

The Department of Surgery, University of Lund, Lund, Sweden and the Department of Anesthesiology, University of Lund, Malmö, Sweden
Evita Zoucas

The Department of Surgery, University of Lund, Lund, Sweden and the Department of Anesthesiology, University of Lund, Malmö, Sweden

Abstract

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Summary

The effect of ethanol intoxication on hemostasis after liver resection was studied in the rat. Plasma levels of ethanol were within the range of those found in ethanol intoxication in man. Bleeding time and blood loss were significantly increased, whereas hemoglobin and hematocrit values were decreased after resection in intoxicated animals compared to controls. APT-times and platelet counts did not differ significantly between the two groups of rats. ADP- and collagen-induced platelet aggregation was slightly inhibited one hour after ethanol administration in non-operated animals. A decrease in pH, such as observed in intoxicated animals, did not affect hemostasis. Distribution of cardiac output was significantly altered after ethanol intoxication. Renal blood flow was increased by 54%, blood flow in the hepatic artery by 40% and in the portal vein by 47%.

Keywords

Ethanol-intoxication - Bleeding time - Blood loss - Platelet aggregation

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Referenzen

References
1 Sullivan L, Herbert V. Suppression of hematopoiesis by ethanol. J Clin Invest 1964; 43: 2048-2061
2 Cowan DW. Thrombokinetic studies in alcohol related thrombocytopenia. J Lab Clin Med 1973; 81: 64-76
3 Myrhed M, Berglund L, Böttiger L-E. Alcohol consumption and hematology. Acta Med Scand 1977; 202: 11-15
4 Lindenbaum J, Lieber CS. Hematologic effects of alcohol in man in the absence of nutritional deficiency. N Engl J Med 1969; 281: 333-338
5 Böttinger LE. Alcohol and the blood. Scand J Haematol 1973; 10: 321-326
6 Haut M, Cowan DH. The effect of ethanol on hemostatic properties of human blood platelets. Am J Med 1974; 56: 22-33
7 Davis JW, Phillips Ph. The effect of ethanol on human platelet aggregation in vitro. Atherosclerosis 1970; 11: 473-477
8 Elmer O, Göransson G, Bengmark S. Ethanol-induced microaggregate formation in pig and rabbit blood. An in vitro study. Thromb Diath Haemorrh 1977; 37: 344-349
9 Starling EH. The action of Alcohol on Man. Longmans, London 1923
10 Mendeloff AI. Effect of intravenous infusions of ethanol upon estimated blood flow in man. J Clin Invest 1954; 33: 1298-1302
11 Castenfors H, Hultman E, Josephson B. Effect of intravenous infusions of ethyl alcohol on estimated hepatic blood flow in man. J Clin Invest 1960; 39: 776-781
12 Childs A, Kivel R, Lieberman A. Effect of ethyl alcohol on hepatic circulation, sulfobromophthalein clearance and hepatic glutaminoxalecetic transaminase production in man. Gastroenterology 1963; 45: 176-181
13 McDermott TF. Alcohol, road crash casualties and countermeasures. NZ J Surg 1977; 47: 156-161
14 van Kampen EJ, Zijlstra WG. Standardization of hemoglobinometry. Clin Chim Acta 1961; 6: 538-544
15 Proctor RP, Rapaport SI. The partial thromboplastin time with kaolin. Am J Clin Pathol 1961; 36: 212-219
16 Born GV R, Cross MJ. The aggregation of blood platelets. J Physiol 1963; 168: 178-195
17 Himwich HE, Nahum LH, Rakiolen N, Fazikas JF, Dubois D, Gildea EF. The metabolism of alcohol. J Am Med Ass 1933; 100: 651-654
18 Kreiberg RA, Owen WC, Siegel AM. Ethanol-induced hyperlacticacidemia: Inhibition of lactate utilization. J Clin Invest 1971; 50: 166-174
19 Hardaway RM, Elovitz MJ, Brewster WR, Houchin DN. Clotting time of heparinized blood. Arch Surg 1964; 89: 701-704
20 Crowell JW, Read WL. In vivo coagulation - a probable course of irreversible shock. Am J Physiol 1955; 183: 565-569
21 Kartalis G, Gabrielidis K, Sinakos Z. L'hemostase pendant l'acidose. Société française d'Hématologie. 2^e Congrès, 24–27 Mai 1976 197-200
22 Gutmann I, Wahlefeld AW. L-(+)-Lactate. Determination with lactate dehydrogenase and NAD. In: Bergmeyer HU. (Ed) Methods of Enzymatic Analysis. Verlag Chemie Weinheim and Academic Press Inc. New York and London: (2nd ed) p 1464 1964
23 Sasaki Y, Wagner HN. Measurement of the distribution of cardiac output in unanesthetized rats. J Appl Physiol 1971; 30: 879-884
24 Idvall J, Aronsen K-F, Nilsson L, Nosslin B. Evaluation of the microsphere method for determination of cardiac output and flow distribution in the rat. Europ Surg Res (in press)
25 Mörland J, Holm T, Prydz H. The influence of ethanol feeding on the activities of factors II, VII, VIII, IX and X in rats. Thromb Haemostas (Stuttg) 1976; 36: 532-536
26 Post R, Desforges J. Thrombocytopenic effect of ethanol infusion. Blood 1968; a 31: 344-347
27 Post R, Desforges J. Thrombocytopenia and alcoholism. Ann Int Med 1968; b 68: 1230-1236
28 Karpatkin S, Charmatz A. Heterogeneity of human platelets. J Clin Invest 1969; 48: 1073-1082
29 Ginburg A, Aster R. Changes associated with platelet aging. Thromb Diath Haemorrh 1972; 27: 407-415
30 Born GV R, Bergquist D, Arfors K-E. Evidence for inhibition of platelet activation in blood by a drug effect on erythrocytes. Nature, 1976; 259: 233-234
31 Rubin E, Lieber CS. Experimental alcoholic hepatic injury in man. Ultrastructural changes. Fed Proc 1967; 26: 1458-1467
32 Broesma RJ, Bullemer GD, Mammen EF. Acidosis induced disseminated intravascular microthrombosis and its dissolution by streptokinase. Thromb Diath Haemorrh 1970; 24: 55-67
33 Smythe CMcC, Heinemann HO, Bradley SE. Estimated hepatic blood flow in the dog. Effect of ethyl alcohol on it, renal blood flow, cardiac output and arterial pressure. Am J Physiol 1953; 172: 737-741