The Antithrombogenic In Vivo Effects of Calcium Channel Blockers in Experimental Thrombosis in Mice

M P Ortega; C Sunkel; J G Priego; P R Statkow

doi:10.1055/s-0038-1651117

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1987; 57(03): 283-285
DOI: 10.1055/s-0038-1651117

Original Article

Schattauer GmbH Stuttgart

The Antithrombogenic In Vivo Effects of Calcium Channel Blockers in Experimental Thrombosis in Mice

Authors

M P Ortega

^*The Departamento de Investigación, Alter, S. A., Mateo Inurria, Madrid, Spain
C Sunkel

^*The Departamento de Investigación, Alter, S. A., Mateo Inurria, Madrid, Spain
J G Priego

^*The Departamento de Investigación, Alter, S. A., Mateo Inurria, Madrid, Spain
P R Statkow

^**The Cermol, S. A., Geneva, Switzerland

Abstract

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Summary

A new model of thrombotic challenge, well suited for screening agents and which acts primarily against platelet thromboembolism, has been used to test the in vivo anti-platelet effects of four calcium channel blockers (CCB). An i. v. injection of a mixture of collagen plus epinephrine (15 μg and 1.8 μg/mouse, respectively) was given to male mice. 94% control mice died or remained paralyzed for more than 15 minutes. The dihydropyridine agents, CRE-223 and Nifedipine, were highly protective against experimental thrombosis, whereas Verapamil had a weaker and much shorter effect and, on the other hand, Diltiazem had no protective effect over a range of doses. The activity on both dihydropyridines lasted for seven hours or even longer.

Keywords

Calcium channel blockers - Antithrombotic agents - Thrombosis model - Dihydropyridines - Verapamil - Diltiazem

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Referenzen

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